Property Summary

NCBI Gene PubMed Count 17
PubMed Score 11.31
PubTator Score 11.51

Knowledge Summary


No data available


  Differential Expression (8)

Disease log2 FC p
psoriasis 2.200 4.8e-20
cutaneous lupus erythematosus 1.100 4.2e-04
astrocytoma 1.500 4.8e-02
glioblastoma 1.600 2.1e-03
adrenocortical carcinoma -1.367 1.1e-04
tuberculosis 1.400 1.7e-04
subependymal giant cell astrocytoma 2.727 1.1e-03
ovarian cancer 1.200 5.9e-03

Gene RIF (7)

26372645 Data suggest ADAP2 (an interferon-beta stimulated gene) disrupts pathogenic internalization of some RNA viruses/virions (dengue, vesicular stomatitis) by altering ADP ribosylation factor 6-mediated processes including up-regulation of pinocytosis.
23285209 Centaurin-alpha interacts with beta-tubulin and stabilizes microtubules.
20546612 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19291764 Observational study of gene-disease association. (HuGE Navigator)
19266077 Observational study of gene-disease association. (HuGE Navigator)
14690521 The human gene for centaurin alpha 2 is located on chromosome 17, position 17q11.2, near the neurofibromatosis 1 (NF1) locus and concentrated at the plasma membrane.

AA Sequence

EWLESLRGVLSSPLTPLNRLTASTESGRSSR                                           351 - 381

Text Mined References (17)

PMID Year Title
26372645 2015 ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.
23285209 2012 Centaurin-?? interacts with ?-tubulin and stabilizes microtubules.
20546612 2010 The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20098747 2010 Expanding the substantial interactome of NEMO using protein microarrays.
19291764 2009 RNF135 mutations are not present in patients with Sotos syndrome-like features.
19266077 2009 Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.
18482256 2009 Protein microarray analysis identifies human cellular prion protein interactors.
18391951 2008 Many sequence variants affecting diversity of adult human height.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16138909 2005 Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14690521 2004 Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12018390 2002 Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle.
10843809 2000 A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.