| Tdark | Long-chain-fatty-acid--CoA ligase ACSBG2 |
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 3.0e-10 |
| ovarian cancer | 8520 | 1.1e-08 |
| medulloblastoma, large-cell | 6241 | 2.1e-03 |
| lung cancer | 4740 | 3.4e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Adrenoleukodystrophy | 29 | 3.475 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| lung cancer | 1.300 | 3.4e-03 |
| medulloblastoma, large-cell | 1.300 | 2.1e-03 |
| ovarian cancer | 1.100 | 1.1e-08 |
| psoriasis | -1.100 | 3.0e-10 |
MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRESVNRFGTYPAL 1 - 70 ASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNS 71 - 140 AEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDT 141 - 210 QLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQM 211 - 280 MDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWAR 281 - 350 NIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELY 351 - 420 GLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEG 421 - 490 WLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLK 491 - 560 CEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEAMNNAQRIEKWVI 561 - 630 LEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMYH 631 - 666 //
