Tchem Acrosin

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Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.

Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]

Comments

Property Summary

Ligand Count	25
NCBI Gene PubMed Count	33
PubMed Score	1039.52

PubTator Score	1106.45

Knowledge Summary

Patent

No data available

TINX Plot

Disease (1)

JensenLab Text Mining

Disease	Target Count	Z-score	Confidence
Infertility	188	4.903	2.5
Male infertility	206	4.497	2.2
Varicocele	26	3.6	1.8

Testis 18,518

Spleen 17,614

Adipose - Subcutaneous 18,110

Breast - Mammary Tissue 18,103

Lung 18,057

Uterus 17,618

Nerve - Tibial 18,007

Vagina 17,834

Adipose - Visceral (Omentum) 17,937

Prostate 18,213

Skin - Sun Exposed (Lower leg) 17,968

Thyroid 18,024

Esophagus - Muscularis 18,017

Minor Salivary Gland 18,005

Kidney - Cortex 17,329

Pituitary 18,147

Esophagus - Gastroesophageal Junction 18,000

Skin - Not Sun Exposed (Suprapubic) 18,081

Brain - Nucleus accumbens (basal ganglia... 18,024

Brain - Caudate (basal ganglia) 18,001

Artery - Coronary 17,949

Artery - Tibial 17,631

Brain - Cortex 18,039

Colon - Sigmoid 18,089

Brain - Spinal cord (cervical c-1) 17,973

Liver 18,071

Small Intestine - Terminal Ileum 17,954

Brain - Putamen (basal ganglia) 17,863

Brain - Frontal Cortex (BA9) 18,069

Brain - Cerebellum 17,983

Stomach 17,879

Colon - Transverse 17,825

Esophagus - Mucosa 18,076

Brain - Cerebellar Hemisphere 18,015

Muscle - Skeletal 17,778

Brain - Anterior cingulate cortex (BA24) 17,989

Artery - Aorta 17,896

Brain - Amygdala 18,006

Brain - Hypothalamus 18,169

Brain - Hippocampus 18,011

Heart - Atrial Appendage 17,896

Heart - Left Ventricle 18,006

Brain - Substantia nigra 17,981

Adrenal Gland 18,071

Ovary 17,971

Pancreas 18,123

Cells - Transformed fibroblasts 17,577

Cells - EBV-transformed lymphocytes 18,186

Whole Blood 17,439

Adult Testis 10,836

Adult Ovary 10,192

Adult Pancreas 9,168

Fetal Gut 8,640

Ovary

Testis

adipose tissue 15,837

appendix 16,247

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

placenta 15,937

prostate 16,460

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

smooth muscle 15,857

spleen 15,972

testis 17,936

thyroid gland 15,959

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Leukocyte 206

Testis 3,897

See source...

Semen 285

Germ cell 264

Spermatid 138

Epididymis 92

Cervical mucus 16

Ascidian 30

Epididymal fluid 18

Seminal vesicle 29

Seminiferous tubule 32

Vagina 93

Urine 298

Accessory sex gland 14

See source...

Synonym

Accession	P10323 Q6ICK2
Symbols

Gene

ACR

PANTHER Protein Class (3)

hydrolase 762

protease 516

serine protease 175

Ortholog (10)

Species	Source	Disease
Opossum 12,223	OMA EggNOG
Chicken 7,823	Inparanoid OMA
Chimp 14,136	Inparanoid OMA EggNOG
Macaque 12,758	Inparanoid OMA EggNOG
Mouse 16,567	Inparanoid OMA EggNOG
Rat 15,112	Inparanoid OMA EggNOG
Dog 15,069	Inparanoid OMA EggNOG
Horse 14,249	Inparanoid OMA EggNOG
Cow 15,316	Inparanoid OMA EggNOG
Pig 10,164	Inparanoid EggNOG

UniProt Keyword (10)

Complete proteome 20,231

Polymorphism 12,194

Reference proteome 20,231

Disulfide bond 3,599

Glycoprotein 4,623

Hydrolase 1,654

Signal 3,561

Protease 535

Zymogen 215

Serine protease 142

GO Function (9)

DNA binding 1,481

zinc ion binding 828

serine-type endopeptidase activity 246

protease binding 108

copper ion binding 54

drug binding 75

mannose binding 17

fucose binding 4

amidase activity 3

GO Component (5)

nucleus 5,097

extracellular region 1,833

protein complex 552

Golgi-associated vesicle 15

acrosomal matrix 4

GO Process (7)

binding of sperm to zona pellucida 37

penetration of zona pellucida 8

single fertilization 58

response to steroid hormone 18

activation of adenylate cyclase activity 38

acrosome reaction 16

acrosome matrix dispersal 1

Compartment GO Term (43)

Acrosomal matrix 11

Acrosomal membrane 23

Acrosomal vesicle 89

Bounding membrane of organelle 1,956

Cell 16,178

Cell part 16,177

Cytoplasm 10,983

Cytoplasmic part 9,247

Cytoplasmic vesicle 2,218

Cytoplasmic vesicle membrane 795

Cytoplasmic vesicle part 1,513

Egg coat 11

Endomembrane system 4,237

Endonuclear canal 2

External encapsulating structure 84

See all...

MGI Phenotype (2)

reproductive system phenotype 1,999

normal phenotype 1,999

HCA RNA Cell Line (22)

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ hTERT+ SV40 Large T+ RasG12V 15,493

CAPAN-2 16,102

EFO-21 17,301

HEK 293 15,853

Hep G2 15,179

HMC-1 16,581

See all...

Pathway (1)

Reproduction 109

Ligand (25)

CHEMBL149156
pIC50 6.52

CHEMBL545564
pIC50 6.52

CHEMBL440176
pIC50 7.00

CHEMBL150009
pIC50 7.42

CHEMBL356950
pIC50 7.48

CHEMBL146905
pIC50 7.55

CHEMBL148833
pIC50 7.56

CHEMBL543454
pIC50 7.70

CHEMBL357708
pIC50 7.75

CHEMBL148731
pIC50 7.79

CHEMBL149157
pIC50 7.86

CHEMBL148957
pIC50 7.89

CHEMBL147344
pIC50 7.94

CHEMBL540096
pIC50 8.03

CHEMBL539058
pIC50 8.10

CHEMBL542261
pIC50 8.14

CHEMBL149135
pIC50 8.18

CHEMBL149324
pIC50 8.25

CHEMBL542258
pIC50 8.27

CHEMBL358868
pIC50 8.46

See all 25 ligands...

Gene RIF (4)

AA Sequence

MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRY      1 - 70
HTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEG     71 - 140
NDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCN    141 - 210
STQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWP    211 - 280
YLNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSP    281 - 350
PPPPPPPASPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTST    351 - 420
S//

Text Mined References (33)

Summary
Details

	PMID	Year	Title

Tchem Acrosin Add to cart View Collections Empty Collection