Tchem | Acrosin |
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]
Comments
Property Summary
Ligand Count | 25 |
NCBI Gene PubMed Count | 33 |
PubMed Score | 1039.52 |
PubTator Score | 1106.45 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Infertility | 188 | 4.903 | 2.5 |
Male infertility | 206 | 4.497 | 2.2 |
Varicocele | 26 | 3.6 | 1.8 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid EggNOG |
CHEMBL149156
pIC50 6.52
CHEMBL545564
pIC50 6.52
CHEMBL440176
pIC50 7.00
CHEMBL150009
pIC50 7.42
CHEMBL356950
pIC50 7.48
CHEMBL146905
pIC50 7.55
CHEMBL148833
pIC50 7.56
CHEMBL543454
pIC50 7.70
CHEMBL357708
pIC50 7.75
CHEMBL148731
pIC50 7.79
CHEMBL149157
pIC50 7.86
CHEMBL148957
pIC50 7.89
CHEMBL147344
pIC50 7.94
CHEMBL540096
pIC50 8.03
CHEMBL539058
pIC50 8.10
CHEMBL542261
pIC50 8.14
CHEMBL149135
pIC50 8.18
CHEMBL149324
pIC50 8.25
CHEMBL542258
pIC50 8.27
CHEMBL358868
pIC50 8.46
MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRY 1 - 70 HTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEG 71 - 140 NDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCN 141 - 210 STQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWP 211 - 280 YLNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSP 281 - 350 PPPPPPPASPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTST 351 - 420 S//