| Tbio | Abl interactor 2 |
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3469 | 1.7e-12 |
| juvenile dermatomyositis | 1147 | 6.5e-11 |
| atypical teratoid / rhabdoid tumor | 4971 | 9.4e-09 |
| ovarian cancer | 8297 | 3.3e-08 |
| malignant mesothelioma | 3135 | 2.7e-06 |
| osteosarcoma | 7766 | 8.1e-06 |
| medulloblastoma, large-cell | 6086 | 1.1e-05 |
| tuberculosis | 1963 | 3.1e-05 |
| psoriasis | 6514 | 1.3e-04 |
| glioblastoma | 5635 | 2.7e-04 |
| lung cancer | 4607 | 2.8e-04 |
| chronic rhinosinusitis | 505 | 1.3e-03 |
| pediatric high grade glioma | 1035 | 2.8e-03 |
| spina bifida | 1053 | 2.3e-02 |
| ependymoma | 4559 | 3.3e-02 |
| acute myeloid leukemia | 760 | 3.7e-02 |
| Hydrolethalus syndrome | 126 | 3.9e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3204 | 4.6e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2872 | 4.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired metabolic disease | 329 | 0.0 | 3.0 |
| Atherosclerosis | 276 | 0.0 | 2.1 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | -1.400 | 3.7e-02 |
| atypical teratoid / rhabdoid tumor | 1.500 | 9.4e-09 |
| Breast cancer | -1.100 | 1.7e-12 |
| chronic rhinosinusitis | -1.047 | 1.3e-03 |
| ependymoma | -1.100 | 3.3e-02 |
| glioblastoma | 1.300 | 2.7e-04 |
| Hydrolethalus syndrome | 1.486 | 3.9e-02 |
| intraductal papillary-mucinous adenoma (... | 1.400 | 4.8e-02 |
| intraductal papillary-mucinous neoplasm ... | 2.000 | 4.6e-02 |
| juvenile dermatomyositis | 1.010 | 6.5e-11 |
| lung cancer | 1.400 | 2.8e-04 |
| malignant mesothelioma | -1.100 | 2.7e-06 |
| medulloblastoma, large-cell | 1.500 | 1.1e-05 |
| osteosarcoma | 1.501 | 8.1e-06 |
| ovarian cancer | -2.200 | 3.3e-08 |
| pediatric high grade glioma | 1.200 | 2.8e-03 |
| psoriasis | 1.300 | 1.3e-04 |
| spina bifida | 1.122 | 2.3e-02 |
| tuberculosis | -1.300 | 3.1e-05 |
MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSADKQRALEETKAYTTQSLASVAYLINTLAN 1 - 70 NVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANLERPVRYIRKP 71 - 140 IDYTILDDIGHGVKWLLRFKVSTQNMKMGGLPRTTPPTQKPPSPPMSGKGTLGRHSPYRTLEPVRPPVVP 141 - 210 NDYVPSPTRNMAPSQQSPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPS 211 - 280 VFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPNAAAGGAPNLADGFTSPTPPVVSSTPPTGHPVQF 281 - 350 YSMNRPASRHTPPTIGGSLPYRRPPSITSQTSLQNQMNGGPFYSQNPVSDTPPPPPPVEEPVFDESPPPP 351 - 420 PPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYE 421 - 490 GVMNGVTGLFPGNYVESIMHYSE 491 - 513 //
