1. Home
  2. Targets
  3. transcription factor
  4. helix-turn-helix transcription factor
  5. homeobox transcription factor
  6. Homeobox protein Nkx-6.3

Tbio Homeobox protein Nkx-6.3

Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.

The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006 [PubMed 16326147]).[supplied by OMIM, Mar 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 4
PubMed Score 5.74
PubTator Score 0.25

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count Z-score Confidence
Dyslexia 36 3.445 1.7

Expression

Synonym

Accession A6NJ46 Q96LR0
Symbols NKX6.3

Gene

NKX6-3

PANTHER Protein Class (3)

  Ortholog (4)

Species Source
Mouse OMA Inparanoid
Rat OMA Inparanoid
Chicken OMA Inparanoid
Xenopus OMA Inparanoid

 GO Function (1)

 GO Component (1)

 GO Process (5)

 Compartment GO Term (10)

 MGI Term (2)

 HCA RNA Cell Line (16)

See all...

 UniProt Keyword (8)

Gene RIF (2)

PMID Text
26743476 Suggest that NKX6.3 might function as a master regulator of gastric differentiation by affecting SOX2 and CDX2 expression and the NKX6.3 inactivation may result in intestinal metaplasia in gastric epithelial cells.
26314965 Data suggest that NK6 homeobox 3 (NKX6.3) may control the fate of gastric mucosal cells and function as a gastric tumor suppressor.

AA Sequence 

MESNLQGTFLLNNTPLAQFPEMKAPVCQYSVQNSFYKLSPPGLGPQLAAGTPHGITDILSRPVAAPNNSL      1 - 70
LSGYPHVAGFGGLSSQGVYYSPQVGNFSKAGNEYPTRTRNCWADTGQDWRGGRQCSNTPDPLSDSIHKKK     71 - 140
HTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSALEPSSSTPRAP    141 - 210
GGAGAGAGGDRAPSENEDDEYNKPLDPDSDDEKIRLLLRKHRAAFSVLSLGAHSV                   211 - 265
//

Text Mined References (6)

PMID Year Title
26743476 2016 Inactivation of NKX6.3 in the stomach leads to abnormal expression of CDX2 and SOX2 required for gastric-to-intestinal transdifferentiation.
26314965 2015 NKX6.3 controls gastric differentiation and tumorigenesis.
16421571 2006 DNA sequence and analysis of human chromosome 8.
16326147 2006 Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.