Property Summary

NCBI Gene PubMed Count 18
PubMed Score 3.10
PubTator Score 3.17

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count
Crohn Disease 97
Obesity 616
Disease Target Count P-value
intraductal papillary-mucinous adenoma (IPMA) 2956 8.74607053944203E-6
ulcerative colitis 2087 1.96240461294131E-5
ovarian cancer 8492 2.94179432718041E-4
sonic hedgehog group medulloblastoma 1482 3.10370235229428E-4
osteosarcoma 7933 3.27668489247812E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00224514465024018
mucosa-associated lymphoid tissue lymphoma 480 0.00875886579812281
medulloblastoma, large-cell 6234 0.0157413147397352
spina bifida 1064 0.0228948211056843
Disease Target Count Z-score Confidence
Crohn's disease 304 0.0 1.0
Long QT syndrome 53 0.0 2.0
Disease Target Count Z-score Confidence
Wolf-Hirschhorn syndrome 32 3.763 1.9

Expression

Synonym

Accession A1A5C7 A1A5C8 Q5T8B8 Q6ZMH3 Q8IW73
Symbols C6orf85

Gene

  Ortholog (7)

Species Source
Chimp OMA Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Horse OMA Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid

Pathway (1)

Gene RIF (9)

PMID Text
24740203 Genetic variations in the SLC22A23 locus contribute to the susceptibility to inflammatory bowel disease in a small fraction of white patients.
21072187 Observational study of gene-disease association. (HuGE Navigator)
20921969 Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20886065 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19760754 Observational study of gene-disease association. (HuGE Navigator)
19422935 Observational study of gene-disease association. (HuGE Navigator)
19174780 Observational study of gene-disease association. (HuGE Navigator)
19068216 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASAPLGGRAGPGGGAEIQPLPPLHPGGGPHPSCCSAA      1 - 70
AAPSLLLLDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELAGV     71 - 140
TTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGDNASNCDCRAWDYGIRAG    141 - 210
LVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNV    211 - 280
TMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALII    281 - 350
CPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIPELEKELSRRPKKVCIVK    351 - 420
VVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFL    421 - 490
GRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCA    491 - 560
EITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENI    561 - 630
SNGEHYTRQPLLPHKKGEQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM                  631 - 686
//

Text Mined References (21)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24740203 2014 Single-nucleotide polymorphisms in SLC22A23 are associated with ulcerative colitis in a Canadian white cohort.
24204828 2013 Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
21221126 2012 Genome-wide association study of serious blistering skin rash caused by drugs.
21102463 2010 Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
21072187 2010 Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.
20921969 2012 Genome-wide association study of antipsychotic-induced QTc interval prolongation.
20886065 2010 Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
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