Development Level

Tbio 11,651
Tdark 6,593
Tchem 1,388
Tclin 612

Collection

RFA-RM-18-021 328
GPCR: IDG Consortium (Targets) 126
Kinase: IDG Consortium (Target... 125
Ion Channel: IDG Consortium (T... 99
Kinase: IDG Consortium (Comple... 37
GPCR: IDG Consortium (Complete... 25

IMPC Phenotype

preweaning lethality, complete... 979
preweaning lethality, incomple... 499
abnormal behavior 298
embryonic lethality prior to t... 278
embryonic lethality prior to o... 239
abnormal embryo size 220
enlarged heart 210
decreased vertical activity 208
decreased total body fat amoun... 207
abnormal bone structure 187
increased lean body mass 172
abnormal heart morphology 162
decreased body weight 161
decreased bone mineral content 151
hyperactivity 148
decreased lean body mass 135
increased total body fat amoun... 134
hypoactivity 132
decreased circulating glucose ... 126
decreased bone mineral density 126
male infertility 123
increased circulating alkaline... 122
decreased grip strength 116
abnormal seminal vesicle morph... 114
increased startle reflex 112
increased bone mineral content 108
embryonic growth retardation 106
increased or absent threshold ... 101
decreased body length 101
short tibia 97
increased mean corpuscular hem... 96
decreased circulating choleste... 93
increased mean corpuscular vol... 92
cataract 92
prenatal lethality prior to he... 87
decreased lymphocyte cell numb... 83
decreased prepulse inhibition 82
decreased circulating serum al... 82
abnormal lens morphology 81
increased circulating HDL chol... 80
decreased mean corpuscular vol... 79
improved glucose tolerance 79
decreased circulating triglyce... 79
decreased circulating insulin ... 76
increased fasted circulating g... 76
decreased startle reflex 75
impaired glucose tolerance 75
small superior vagus ganglion 74
decreased leukocyte cell numbe... 73
increased bone mineral density 72
increased circulating sodium l... 71
abnormal retina morphology 71
abnormal sleep behavior 70
abnormal gait 69
abnormal eye morphology 68
decreased circulating HDL chol... 68
decreased hemoglobin content 68
increased circulating choleste... 66
abnormal behavioral response t... 66
abnormal kidney morphology 65
decreased fasted circulating g... 65
abnormal coat-hair pigmentatio... 64
increased monocyte cell number 63
increased heart weight 62
decreased erythrocyte cell num... 62
female infertility 60
edema 59
small testis 58
thrombocytopenia 56
abnormal spleen morphology 55
decreased caudal vertebrae num... 53
hydrometra 53
decreased blood urea nitrogen ... 51
decreased mean corpuscular hem... 50
abnormal skin morphology 50
decreased circulating total pr... 49
increased blood urea nitrogen ... 48
decreased circulating alanine ... 47
increased leukocyte cell numbe... 47
increased neutrophil cell numb... 46
decreased circulating alkaline... 46
increased hematocrit 46
decreased hematocrit 46
abnormal neural tube closure 46
increased hemoglobin content 45
increased mean platelet volume 45
abnormal testis morphology 43
abnormal epididymis morphology 42
decreased neutrophil cell numb... 42
increased circulating triglyce... 42
increased grip strength 41
increased circulating chloride... 41
enlarged spleen 41
decreased red blood cell distr... 41
limb grasping 41
increased erythrocyte cell num... 39
decreased circulating creatini... 39
tremors 39
prolonged QT interval 38
abnormal bone mineralization 38

Disease

Carcinoma 11,493
ovarian cancer 8,520
osteosarcoma 7,950
psoriasis 6,694
medulloblastoma, large-cell 6,241
glioblastoma 5,792
atypical teratoid / rhabdoid tumor 5,112
lung cancer 4,740
ependymoma 4,679
group 3 medulloblastoma 4,104
adult high grade glioma 3,801
Breast cancer 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291
malignant mesothelioma 3,232
Astrocytoma, Pilocytic 3,081
primitive neuroectodermal tumor 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955
invasive ductal carcinoma 2,951
non-small cell lung cancer 2,890
oligodendroglioma 2,850
lung carcinoma 2,843
lung adenocarcinoma 2,716
Kidney cancer 2,613
astrocytic glioma 2,597
Cancer 2,499
pancreatic cancer 2,398
interstitial cystitis 2,312
subependymal giant cell astrocytoma 2,287
tuberculosis 2,010
pituitary cancer 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962
Pick disease 1,894
group 4 medulloblastoma 1,855
ulcerative colitis 1,819
ductal carcinoma in situ 1,745
diabetes mellitus 1,728
cystic fibrosis 1,696
breast carcinoma 1,638
colon cancer 1,478
Autosomal recessive predisposition 1,442
adrenocortical carcinoma 1,428
Multiple myeloma 1,332
Rheumatoid arthritis 1,191
juvenile dermatomyositis 1,187
Schizophrenia 1,160
acute quadriplegic myopathy 1,158
astrocytoma 1,146
primary pancreatic ductal adenocarcinoma 1,109
spina bifida 1,074
pediatric high grade glioma 1,064
nasopharyngeal carcinoma 1,058
cutaneous lupus erythematosus 1,057
Intellectual disability 1,016
dermatomyositis 966
Atopic dermatitis 952
active Crohn's disease 922
non primary Sjogren syndrome sicca 891
gastric carcinoma 807
Epilepsy 792
acute myeloid leukemia 783
Liver Cirrhosis, Experimental 769
Waldenstrons macroglobulinemia 765
active ulcerative colitis 764
esophageal adenocarcinoma 737
primary Sjogren syndrome 735
medulloblastoma 720
Melanoma 711
Obesity 678
progressive supranuclear palsy 676
Bipolar Disorder 666
aldosterone-producing adenoma 665
Alzheimer's disease 658
Mental Retardation 645
Low intelligence 645
Mental deficiency 645
Poor school performance 645
Dull intelligence 645
Global developmental delay 608
Cognitive delay 608
Mental and motor retardation 608
Liver cancer 604
Duchenne muscular dystrophy 601
Seizures 596
Muscle hypotonia 571
pancreatic carcinoma 562
fibroadenoma 559
hepatocellular carcinoma 547
Endometriosis 540
Multiple Sclerosis 540
Short stature 531
chronic rhinosinusitis 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510
Down syndrome 499
Prostatic Neoplasms 495
mucosa-associated lymphoid tissue lymphoma 484
Skin cancer 469
posterior fossa group A ependymoma 468
sonic hedgehog group medulloblastoma 467
gastric cancer 459

Tissue

Endocrine System 18,159
Female tissues 17,400
Digestive Tract 17,369
Skin and soft tissues 17,230
Male tissues 17,142
Blood and immune system 16,909
Liver and Pancreas 16,750
Nervous System 16,725
Urinary Tract 16,678
Respiratory system 16,393
Cardiovascular System 15,192

Target Family

Non-IDG 12,091
Enzyme 4,145
Transcription Factor 1,400
Kinase 634
Transporter 473
oGPCR 421
GPCR 408
Ion Channel 344
Epigenetic 242
Nuclear Receptor 48
TF/Epigenetic 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Coiled-coil domain-containing protein 186 CCDC186 Tdark Non-IDG 1.85 0.01 15
Transcription elongation factor A N-terminal and central domain-containing protein 2 TCEANC2 Tdark Non-IDG 1.78 0.02 84
Zinc finger protein 773 ZNF773 Tdark Transcription Factor 1.78 0.02 108
Protein FAM153A FAM153A Tdark Non-IDG 1.72 0.02 12
Protein FAM153C FAM153C Tdark Non-IDG 1.72 0.02 6
Protein FAM117B FAM117B Tdark Non-IDG 1.63 0.11 76
Uncharacterized protein C2orf66 C2orf66 Tdark Non-IDG 1.62 0.02 7
Zinc finger protein 559 ZNF559 Tdark Transcription Factor 1.60 0.02 94
Uncharacterized protein C16orf90 C16orf90 Tdark Non-IDG 1.58 0.03 9
Protein FAM171A1 FAM171A1 Tdark Non-IDG 1.57 0.02 38