Tdark KRTAP12-4 Keratin-associated protein 12-4

Protein Summary

Description

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Uniprot Accession IDs

• P60329
• Q08AF5

Gene Name

• KRTAP12-4

Ensembl ID

• ENST00000391618
• ENSP00000375476
• ENSG00000212933

Symbol

• KAP12.4
• KRTAP12.4
• KRTAP12.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.37
cell line	0.3
tissue	0.29
cellular component	0.25
molecular function	0.15

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.33   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.33   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0