deutetrabenazine
Ligand Summary
The precise mechanism by which deutetrabenazine exerts its anti-chorea effects is unknown but is believed to be related to its effect as a reversible depletor of monoamines (such as dopamine, serotonin, norepinephrine, and histamine) from nerve terminals. The major circulating metabolites (alpha-dihydrotetrabenazine [HTBZ] and beta-HTBZ) of deutetrabenazine, are reversible inhibitors of VMAT2, resulting in decreased uptake of monoamines into synaptic vesicles and depletion of monoamine stores.
UNII: 69ENL3U6BF
PubChem: 45255840
ChEMBL: CHEMBL3137326
DrugCentral: 5226
LyCHI: 44CJ21UJTQZT
Target Activities
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