Name Development Level Target Family
D(2) dopamine receptor Tclin GPCR
5-hydroxytryptamine receptor 2A Tclin GPCR
Name Description
clozapine A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
TCRDv4.6.0
DrugCentral Indication
DrugCentral
clozapine