Name Development Level Target Family
Folate receptor alpha Tchem Non-IDG
Proton-coupled folate transporter Tchem Transporter
Nucleotide-binding oligomerization domain-containing protein 2 Tclin Non-IDG
Folate receptor beta Tchem Non-IDG
DNA topoisomerase 2-alpha Tclin Enzyme
Dihydrofolate reductase Tclin Enzyme
Name Description
methotrexate An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
DrugCentral Indication