Mondo Description A disorder characterized by a strong and persistent cross-gender identification (such as stating a desire to be the other sex or frequently passing as the other sex) coupled with persistent discomfort with his or her sex (manifested in adults, for example, as a preoccupation with altering primary and secondary sex characteristics through hormonal manipulation or surgery).

Disease Ontology Description A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as.