Pharos : Target Details

Tdark

Protein Summary

Description

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Uniprot Accession IDs

Gene Name

ZZZ3

Symbol

ATAC1

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.95

transcription factor binding site profile	0.91

histone modification site profile	0.82

virus perturbation	0.76

cell line	0.64

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.93 (req: < 5)

View Publications

Gene RIFs: 1 (req: <= 3)

View Gene RIFs

Antibodies: 77 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.93 (req: >= 5)

Gene RIFs: 1 (req: > 3)

Antibodies: 77 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (70)

Explore Interacting Targets

1 – 10 of 70

See Interactions on String-DB

MBIP

Tbio

Novelty: 0.05807454

p_int: 0.999999709

p_ni: 2.91e-7

Score: 0.982

Data Source: BioPlex,STRINGDB

DR1

Tbio

Novelty: 0.00138571

p_int: 0.999999661

p_ni: 3.39e-7

Score: 0.908

Data Source: BioPlex,STRINGDB

WDR5

Tchem

Novelty: 0.0059945

p_int: 0.999998556

p_ni: 0.000001444

Score: 0.951

Data Source: BioPlex,STRINGDB

TADA3

Tbio

Novelty: 0.01743814

p_int: 0.999996761

p_ni: 0.000003239

Score: 0.982

Data Source: BioPlex,STRINGDB

IKZF5

Tbio

Family: TF

Novelty: 0.36596327

p_int: 0.99999572

p_ni: 0.00000428

Score: 0.23

Data Source: BioPlex,STRINGDB

CARD8

Tbio

Family: Enzyme

Novelty: 0.0146799

p_int: 0.999834331

p_ni: 0.000165669

Score: 0.473

Data Source: BioPlex,STRINGDB

SGF29

Tbio

Family: Epigenetic

Novelty: 0.0426456

p_int: 0.999713587

p_ni: 0.000286413

Score: 0.968

Data Source: BioPlex,STRINGDB

PSME3

Tbio

Novelty: 0.01051254

p_int: 0.999654778

p_ni: 0.000345222

Score: 0.198

Data Source: BioPlex,STRINGDB

POLE4

Tdark

Family: Enzyme

Novelty: 0.23346084

p_int: 0.999310667

p_ni: 0.000689328

p_wrong: 5e-9

Score: 0.36

Data Source: BioPlex,STRINGDB

PSMC3

Tbio

Family: Enzyme

Novelty: 0.04026019

p_int: 0.999270706

p_ni: 0.000729294

Score: 0.152

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509

Reactome	Chromatin organization	238 targets	R-HSA-4839726

Reactome	HATs acetylate histones	107 targets	R-HSA-3214847

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509

Chromatin organization	238 targets	R-HSA-4839726

HATs acetylate histones	107 targets	R-HSA-3214847

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (3)

Components (3)

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Items per page:

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Model (ISM)	NTNU_SB

DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword

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No Header	No Header
3D-structure

Acetylation

Alternative splicing

Complete proteome

DNA-binding

Isopeptide bond

Metal-binding

Nucleus

Phosphoprotein

Polymorphism

MGI Phenotype

Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID
Chimp	zinc finger ZZ-type containing 3	VGNC:8147	456964

Mouse	zinc finger, ZZ domain containing 3	MGI:1920453	108946

Dog	zinc finger ZZ-type containing 3	VGNC:48871	490203

Horse	zinc finger ZZ-type containing 3	VGNC:25432	100053222

Cow	zinc finger ZZ-type containing 3	VGNC:37397	538498

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger ZZ-type containing 3

Mouse	zinc finger, ZZ domain containing 3

Dog	zinc finger ZZ-type containing 3

Horse	zinc finger ZZ-type containing 3

Cow	zinc finger ZZ-type containing 3

Publication Statistics

PubMed Score 3.93

PubMed score by year

PubTator Score 3.09

PubTator score by year

Related Publications

Text Mined References (11)

GeneRif Annotations (1)

Items per page:

0 of 0

PMID	Year	Title