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Tbio
ZYX
Zyxin

Protein Summary
Description
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322764
  • ENSP00000324422
  • ENSG00000159840
  • ENST00000392910
  • ENSP00000376642
  • ENST00000645637
  • ENSP00000495629
  • ENSG00000285443
  • ENST00000646695
  • ENSP00000494798

Symbol
  • ESP-2
  • HED-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
PubMedID
0.91
cellular component
0.85
transcription factor binding site profile
0.84
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.77   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 361   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.77   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
CCAR1
Tbio
Novelty:  0.03257229
p_int:  0.999996189
p_ni:  0.000003811
Score:  0.854
Data Source:  BioPlex,STRINGDB
TANC2
Tdark
Novelty:  0.08495328
p_int:  0.99999284
p_ni:  0.00000716
Score:  0.369
Data Source:  BioPlex,STRINGDB
VASP
Tbio
Novelty:  0.00041984
p_int:  0.999989557
p_ni:  0.000010443
Score:  0.998
Data Source:  BioPlex,STRINGDB
ENAH
Tbio
Novelty:  0.02329247
p_int:  0.999973444
p_ni:  0.000026556
Score:  0.839
Data Source:  BioPlex,STRINGDB
FKBP15
Tbio
Novelty:  0.0570695
p_int:  0.999973394
p_ni:  0.000026606
Score:  0.185
Data Source:  BioPlex,STRINGDB
SECISBP2L
Tdark
Novelty:  0.03341871
p_int:  0.999951086
p_ni:  0.000048155
p_wrong:  7.59e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
ZFR
Tbio
Novelty:  0.01859772
p_int:  0.999688391
p_ni:  0.000311609
Score:  0.179
Data Source:  BioPlex,STRINGDB
CDPF1
Tdark
Novelty:  0.85714286
p_int:  0.998642402
p_ni:  0.001357597
p_wrong:  1e-9
Data Source:  BioPlex
TUFT1
Tbio
Novelty:  0.01999031
p_int:  0.996810504
p_ni:  0.003189476
p_wrong:  2e-8
Score:  0.5
Data Source:  BioPlex,STRINGDB
FHL3
Tbio
Novelty:  0.11505924
p_int:  0.996381109
p_ni:  0.003618891
Score:  0.34
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
89.2
serum gamma-glutamyl transferase measurement
2
2
2
89.2
basophil count
3
1
3
85.2
basophil count
3
1
3
85.2
basophil percentage of leukocytes
1
1
1
84.9
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
89.2
serum gamma-glutamyl transferase measurement
2
89.2
basophil count
3
85.2
basophil count
3
85.2
basophil percentage of leukocytes
1
84.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zyxin
VGNC:4593
463807
Macaque
zyxin
706407
Mouse
MGI:103072
22793
Rat
RGD:620698
114636
Dog
zyxin
VGNC:51838
482736
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zyxin
Macaque
zyxin
Mouse
Rat
Dog
zyxin
Publication Statistics
PubMed Score 274.77
PubMed score by year
PubTator Score 89.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title