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Tbio
ZYG11B
Protein zyg-11 homolog B

Protein Summary
Description
Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294353
  • ENSP00000294353
  • ENSG00000162378

Symbol
  • KIAA1730
  • ZYG11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor perturbation
0.8
cellular component
0.77
cell type or tissue
0.72
virus perturbation
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.09   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.09   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
PYCARD
Tbio
Novelty:  0.00719985
p_int:  0.999890889
p_ni:  0.000109111
Score:  0.183
Data Source:  BioPlex,STRINGDB
MRM1
Tbio
Family:  Enzyme
Novelty:  0.08762499
p_int:  0.997541621
p_ni:  0.002458379
Data Source:  BioPlex
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.996523761
p_ni:  0.003476239
Data Source:  BioPlex
WFDC9
Tdark
Novelty:  3.44827586
p_int:  0.991273579
p_ni:  0.008726421
Score:  0.189
Data Source:  BioPlex,STRINGDB
AZU1
Tbio
Family:  Enzyme
Novelty:  0.00267169
p_int:  0.986137917
p_ni:  0.013862083
Data Source:  BioPlex
NECAP2
Tdark
Novelty:  0.4141034
p_int:  0.980566008
p_ni:  0.019433992
Data Source:  BioPlex
CLPSL1
Tdark
Family:  Enzyme
Novelty:  0.32091586
p_int:  0.980375742
p_ni:  0.019624258
Score:  0.183
Data Source:  BioPlex,STRINGDB
ST6GAL1
Tchem
Family:  Enzyme
Novelty:  0.00274127
p_int:  0.975980388
p_ni:  0.024019612
Data Source:  BioPlex
AP3S1
Tbio
Novelty:  0.12425009
p_int:  0.975843938
p_ni:  0.024156062
Data Source:  BioPlex
PRSS50
Tbio
Family:  Enzyme
Novelty:  0.01511883
p_int:  0.973155429
p_ni:  0.026844571
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
2
3
89
monocyte count
2
2
2
83.4
hemoglobin measurement
2
2
2
82.7
red blood cell density measurement
1
1
1
67.9
mean reticulocyte volume
1
1
1
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
89
monocyte count
2
83.4
hemoglobin measurement
2
82.7
red blood cell density measurement
1
67.9
mean reticulocyte volume
1
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zyg-11 family member B, cell cycle regulator
VGNC:9401
738327
Macaque
zyg-11 family member B, cell cycle regulator
715671
Mouse
MGI:2685277
414872
Rat
RGD:1307814
362559
Dog
zyg-11 family member B, cell cycle regulator
VGNC:48869
482495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zyg-11 family member B, cell cycle regulator
Macaque
zyg-11 family member B, cell cycle regulator
Mouse
Rat
Dog
zyg-11 family member B, cell cycle regulator
Publication Statistics
PubMed Score 8.09
PubMed score by year
PubTator Score 0.70
PubTator score by year
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Related Publications
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PMID
Year
Title