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Tbio
ZYG11A
Protein zyg-11 homolog A

Protein Summary
Description
Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371528
  • ENSP00000360583
  • ENSG00000203995
  • ENST00000371532
  • ENSP00000360587
  • ENST00000612017
  • ENSP00000482761

Symbol
  • ZYG11
  • ZYG11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.9
tissue sample
0.89
gene perturbation
0.78
microRNA
0.5
histone modification site profile
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.21   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.21   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
ZNF695
Tdark
Family:  TF
Novelty:  0.37164664
p_int:  0.999993987
p_ni:  0.000006013
Score:  0.187
Data Source:  BioPlex,STRINGDB
ZNF264
Tdark
Family:  TF
Novelty:  0.32927591
p_int:  0.999993891
p_ni:  0.000006098
p_wrong:  1e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
FEZ1
Tbio
Novelty:  0.02695814
p_int:  0.999991041
p_ni:  0.000008959
Score:  0.347
Data Source:  BioPlex,STRINGDB
ZNF483
Tdark
Family:  TF
Novelty:  0.39891191
p_int:  0.999990549
p_ni:  0.000009451
Score:  0.163
Data Source:  BioPlex,STRINGDB
ZNF169
Tdark
Family:  TF
Novelty:  1.09432767
p_int:  0.99979187
p_ni:  0.000149758
p_wrong:  0.000058373
Data Source:  BioPlex
C16orf45
Tbio
Novelty:  0.00913059
p_int:  0.998898083
p_ni:  0.001101916
Score:  0.189
Data Source:  BioPlex,STRINGDB
CUL2
Tbio
Novelty:  0.00512916
Score:  0.942
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.731
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.703
Data Source:  STRINGDB
ZER1
Tbio
Novelty:  0.02989698
Score:  0.655
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
4
3
4
82.9
monocyte count
3
3
3
78.2
hemoglobin measurement
3
3
3
74.6
red blood cell density measurement
1
1
1
57.9
mean reticulocyte volume
1
1
1
51
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
4
82.9
monocyte count
3
78.2
hemoglobin measurement
3
74.6
red blood cell density measurement
1
57.9
mean reticulocyte volume
1
51
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zyg-11 family member A, cell cycle regulator
VGNC:9400
456861
Mouse
MGI:2446208
230590
Rat
RGD:1309582
313482
Dog
zyg-11 family member A, cell cycle regulator
VGNC:48868
610740
Horse
zyg-11 family member A, cell cycle regulator
VGNC:50794
100061512
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zyg-11 family member A, cell cycle regulator
Mouse
Rat
Dog
zyg-11 family member A, cell cycle regulator
Horse
zyg-11 family member A, cell cycle regulator
Publication Statistics
PubMed Score 10.21
PubMed score by year
PubTator Score 2.15
PubTator score by year
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Related Publications
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PMID
Year
Title