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Tbio
ZWINT
ZW10 interactor

Protein Summary
Description
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361148
  • ENSP00000354921
  • ENSG00000122952
  • ENST00000373944
  • ENSP00000363055
  • ENST00000395405
  • ENSP00000378801

Symbol
  • SIP30
  • ZWINT1
  • KNTC2AP
  • HZwint-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
co-expressed gene
0.99
disease perturbation
0.97
histone modification site profile
0.93
PubMedID
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.85   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.85   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (296)
DSN1
Tbio
Novelty:  0.05336903
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
NSL1
Tbio
Novelty:  0.01396984
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
SPC25
Tbio
Novelty:  0.26354244
p_int:  0.999999993
p_ni:  7e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  0.999999802
p_ni:  1.98e-7
Score:  0.804
Data Source:  BioPlex,STRINGDB
KNL1
Tbio
Novelty:  0.01084826
p_int:  0.999981973
p_ni:  0.000018027
Score:  0.999
Data Source:  BioPlex,STRINGDB
MTMR6
Tbio
Family:  Enzyme
Novelty:  0.13067072
p_int:  0.999936628
p_ni:  0.000063372
Score:  0.171
Data Source:  BioPlex,STRINGDB
NDC80
Tbio
Novelty:  0.00331814
p_int:  0.999919856
p_ni:  0.000080134
p_wrong:  1e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
SPC24
Tbio
Novelty:  0.03166479
p_int:  0.999918493
p_ni:  0.000081507
Score:  0.997
Data Source:  BioPlex,STRINGDB
MIS12
Tbio
Novelty:  0.05345698
p_int:  0.999881442
p_ni:  0.000118557
Score:  0.997
Data Source:  BioPlex,STRINGDB
LYRM4
Tbio
Novelty:  0.03319832
p_int:  0.999818204
p_ni:  0.000031862
p_wrong:  0.000149935
Score:  0.167
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ZW10 interacting kinetochore protein
VGNC:5884
450469
Macaque
ZW10 interacting kinetochore protein
702198
Mouse
MGI:1289227
52696
Rat
RGD:628671
257644
Dog
ZW10 interacting kinetochore protein
VGNC:48866
477579
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ZW10 interacting kinetochore protein
Macaque
ZW10 interacting kinetochore protein
Mouse
Rat
Dog
ZW10 interacting kinetochore protein
Publication Statistics
PubMed Score 50.85
PubMed score by year
PubTator Score 21.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title