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Tbio
ZWILCH
Protein zwilch homolog

Protein Summary
Description
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307897
  • ENSP00000311429
  • ENSG00000174442
  • ENST00000446801
  • ENSP00000402217
  • ENST00000535141
  • ENSP00000437749
  • ENST00000565627
  • ENSP00000454737
  • ENST00000613446
  • ENSP00000477955

Symbol
  • KNTC1AP
  • hZwilch
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
transcription factor binding site profile
0.8
transcription factor perturbation
0.74
gene perturbation
0.73
PubMedID
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (212)
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.99981314
p_ni:  0.000176734
p_wrong:  0.000010126
Score:  0.163
Data Source:  BioPlex,STRINGDB
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.999389086
p_ni:  0.000610914
Data Source:  BioPlex
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
p_int:  0.997919223
p_ni:  0.002029387
p_wrong:  0.000051391
Data Source:  BioPlex
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.992810583
p_ni:  0.004375924
p_wrong:  0.002813493
Data Source:  BioPlex
C12orf49
Tdark
Novelty:  0.56030929
p_int:  0.949745216
p_ni:  0.021140755
p_wrong:  0.029114029
Score:  0.243
Data Source:  BioPlex,STRINGDB
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.789809478
p_ni:  0.001503433
p_wrong:  0.208687089
Data Source:  BioPlex
ZW10
Tbio
Novelty:  0.01680538
Score:  0.998
Data Source:  Reactome,STRINGDB
KNTC1
Tbio
Novelty:  0.08083785
Score:  0.998
Data Source:  Reactome,STRINGDB
MAD2L1
Tbio
Novelty:  0.01623659
Score:  0.993
Data Source:  STRINGDB
NDC80
Tbio
Novelty:  0.00331814
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
87.5
triglyceride measurement
3
2
3
63.6
2
2
0
1.1
60.8
lymphocyte count
2
2
2
59.4
mathematical ability
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
87.5
triglyceride measurement
3
63.6
0
1.1
60.8
lymphocyte count
2
59.4
mathematical ability
1
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zwilch kinetochore protein
VGNC:1573
453528
Macaque
zwilch kinetochore protein
710680
Mouse
MGI:1915264
68014
Rat
RGD:1583880
691493
Dog
zwilch kinetochore protein
VGNC:48865
478349
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zwilch kinetochore protein
Macaque
zwilch kinetochore protein
Mouse
Rat
Dog
zwilch kinetochore protein
Publication Statistics
PubMed Score 14.68
PubMed score by year
PubTator Score 4.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title