Tbio ZW10 Centromere/kinetochore protein zw10 homolog

Protein Summary

Description

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• O43264
• A1A528

Gene Name

• ZW10

Ensembl ID

• ENST00000200135
• ENSP00000200135
• ENSG00000086827
• ENST00000535142
• ENSP00000440879

Symbol

• HZW10
• KNTC1AP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
interacting protein	0.98
tissue sample	0.81
disease perturbation	0.79
transcription factor binding site profile	0.73

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Centromere/kinetochore Protein Zw10 Homolog

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Centromere/kinetochore Protein Zw10 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.16   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.16   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (222)

Explore Interacting Targets

1 – 10 of 222

• See Interactions on String-DB

RINT1

Tbio

Novelty:  0.04546291

p_int:  0.999973445

p_ni:  0.000026555

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

SCFD2

Tdark

Novelty:  0.38252131

p_int:  0.999799681

p_ni:  0.000200319

Score:  0.942

Data Source:  BioPlex,STRINGDB

STX18

Tbio

Novelty:  0.0259034

p_int:  0.986892875

p_ni:  0.013107124

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

USE1

Tbio

Novelty:  0.00904756

p_int:  0.985396769

p_ni:  0.014603231

Score:  0.987

Data Source:  BioPlex,Reactome,STRINGDB

CMKLR1

Tchem

Family:  GPCR

Novelty:  0.00893083

p_int:  0.966225469

p_ni:  0.033774531

Data Source:  BioPlex

VAMP5

Tbio

Novelty:  0.09958312

p_int:  0.96145128

p_ni:  0.03854872

Data Source:  BioPlex

SEC22B

Tbio

Novelty:  0.03035448

p_int:  0.93552475

p_ni:  0.06447525

Score:  0.98

Data Source:  BioPlex,STRINGDB

EFNA5

Tbio

Novelty:  0.00134985

p_int:  0.916241521

p_ni:  0.083758479

Data Source:  BioPlex

BSG

Tbio

Novelty:  0.0010285

p_int:  0.912142121

p_ni:  0.087857879

Data Source:  BioPlex

FZD10

Tbio

Family:  GPCR

Novelty:  0.02786933

p_int:  0.882260499

p_ni:  0.117739501

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (21)

Reactome (21)

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Reactome	Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Reactome	COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620

Name	Explore in Pharos	Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Amplification of signal from the kinetochores	93 targets	R-HSA-141424
COPI-dependent Golgi-to-ER retrograde traffic	83 targets	R-HSA-6811434
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (26)

Functions (1)

Components (11)

Processes (14)

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10

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GO Term	Evidence	Assigned by
centromeric DNA binding	Traceable Author Statement (TAS)	ProtInc

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alcohol consumption measurement	EFO_0007878	4	4	4		64.3
smoking status measurement	EFO_0006527	2	1	2		57.3
Age-related nuclear cataract	HP_0011142	1	1	0	6.3	40.7
self reported educational attainment	EFO_0004784	1	1	1		31.4
parental longevity	EFO_0007796	1	1	1		28.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alcohol consumption measurement	EFO_0007878	4		64.3
smoking status measurement	EFO_0006527	2		57.3
Age-related nuclear cataract	HP_0011142	0	6.3	40.7
self reported educational attainment	EFO_0004784	1		31.4
parental longevity	EFO_0007796	1		28.1

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosome
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton

GWAS Trait Find Similar Targets

No Header	No Header
Age-related nuclear cataract
alcohol consumption measurement
chronic lymphocytic leukemia
low density lipoprotein cholesterol measurement
mathematical ability
parental longevity
self reported educational attainment
sex hormone-binding globulin measurement
smoking status measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zw10 kinetochore protein	VGNC:930	451554
Macaque	zw10 kinetochore protein		694436
Mouse	zw10 kinetochore protein	MGI:1349478	26951
Rat	zw10 kinetochore protein	RGD:1309197	363059
Dog	zw10 kinetochore protein	VGNC:48864	479433

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zw10 kinetochore protein
Macaque	zw10 kinetochore protein
Mouse	zw10 kinetochore protein
Rat	zw10 kinetochore protein
Dog	zw10 kinetochore protein

Publication Statistics

PubMed Score 58.16

PubMed score by year

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PubTator Score 31.97

PubTator score by year

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Related Publications

Text Mined References (37)

GeneRif Annotations (13)

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PMID	Year	Title