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Tdark
ZSWIM8
Zinc finger SWIM domain-containing protein 8

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398706
  • ENSP00000381693
  • ENSG00000214655
  • ENST00000605216
  • ENSP00000474748

Symbol
  • KIAA0913
  • KIAA0913
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.67
transcription factor binding site profile
0.66
tissue sample
0.64
tissue
0.58
transcription factor
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.53   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 5   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.53   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
DCLRE1C
Tbio
Novelty:  0.01064408
p_int:  0.999999704
p_ni:  2.96e-7
Score:  0.2
Data Source:  BioPlex,STRINGDB
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.999999302
p_ni:  6.98e-7
Data Source:  BioPlex
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.999972308
p_ni:  0.00002769
p_wrong:  2e-9
Data Source:  BioPlex
ASB3
Tbio
Novelty:  0.15921018
p_int:  0.999479899
p_ni:  0.000520055
p_wrong:  4.6e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
TULP2
Tdark
Family:  TF
Novelty:  0.20144336
p_int:  0.993289376
p_ni:  0.00651579
p_wrong:  0.000194834
Score:  0.183
Data Source:  BioPlex,STRINGDB
OLFM2
Tbio
Novelty:  0.06929963
p_int:  0.976749817
p_ni:  0.021009833
p_wrong:  0.002240351
Data Source:  BioPlex
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.955512276
p_ni:  0.043452207
p_wrong:  0.001035516
Data Source:  BioPlex
ELOC
Tbio
Novelty:  0.00964847
Score:  0.982
Data Source:  STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.957
Data Source:  STRINGDB
CUL2
Tbio
Novelty:  0.00512916
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Regulation of expression of SLITs and ROBOs
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Regulation of expression of SLITs and ROBOs
Signaling by ROBO receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
2
2
76.4
C-reactive protein measurement
2
2
2
68.5
FEV/FEC ratio
1
2
2
63.6
1
1
0
1.1
61.4
serum gamma-glutamyl transferase measurement
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
2
76.4
C-reactive protein measurement
2
68.5
FEV/FEC ratio
2
63.6
0
1.1
61.4
serum gamma-glutamyl transferase measurement
1
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger SWIM-type containing 8
VGNC:7881
450527
Mouse
MGI:1919156
268721
Rat
RGD:1309414
361004
Dog
zinc finger SWIM-type containing 8
VGNC:48861
100856202
Horse
zinc finger SWIM-type containing 8
VGNC:25424
100064078
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger SWIM-type containing 8
Mouse
Rat
Dog
zinc finger SWIM-type containing 8
Horse
zinc finger SWIM-type containing 8
Publication Statistics
PubMed Score 4.53
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title