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Tbio
ZSWIM7
Zinc finger SWIM domain-containing protein 7

Protein Summary
Description
Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399277
  • ENSP00000382218
  • ENSG00000214941
  • ENST00000472495
  • ENSP00000419138

Symbol
  • SWS1
  • SWS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
transcription factor perturbation
0.8
disease perturbation
0.68
kinase perturbation
0.66
transcription factor binding site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.99   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.99   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
SWSAP1
Tbio
Family:  Enzyme
Novelty:  0.39530563
p_int:  0.999968245
p_wrong:  0.000031755
Score:  0.988
Data Source:  BioPlex,STRINGDB
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
p_int:  0.999547132
p_ni:  1.17e-7
p_wrong:  0.000452751
Score:  0.558
Data Source:  BioPlex,STRINGDB
POLD1
Tclin
Family:  Enzyme
Novelty:  0.00508209
Score:  0.941
Data Source:  STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
Score:  0.901
Data Source:  STRINGDB
CETN2
Tbio
Novelty:  0.00641301
Score:  0.9
Data Source:  STRINGDB
MSH2
Tbio
Novelty:  0.00054283
Score:  0.9
Data Source:  STRINGDB
XRCC4
Tbio
Novelty:  0.00305644
Score:  0.9
Data Source:  STRINGDB
RAD23B
Tbio
Novelty:  0.00672104
Score:  0.9
Data Source:  STRINGDB
NHEJ1
Tbio
Novelty:  0.00773499
Score:  0.9
Data Source:  STRINGDB
PRKDC
Tchem
Family:  Kinase
Novelty:  0.00107984
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
60.5
body mass index
2
1
2
57.3
body height
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
60.5
body mass index
2
57.3
body height
1
29
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger SWIM-type containing 7
VGNC:14551
100614106
Macaque
zinc finger SWIM-type containing 7
100425037
Mouse
MGI:1916997
69747
Rat
RGD:1310324
287388
Dog
zinc finger SWIM-type containing 7
VGNC:48860
479517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger SWIM-type containing 7
Macaque
zinc finger SWIM-type containing 7
Mouse
Rat
Dog
zinc finger SWIM-type containing 7
Publication Statistics
PubMed Score 3.99
PubMed score by year
PubTator Score 25.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title