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Tbio
ZSWIM6
Zinc finger SWIM domain-containing protein 6

Protein Summary
Description
The protein encoded by this gene contains a zinc finger SWI2/SNF2 and MuDR (SWIM) domain. Proteins with SWIM domains have been found in a diverse number of species and are predicted to interact with DNA or proteins. Mutations in this gene result in acromelic frontonasal dysostosis. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252744
  • ENSP00000252744
  • ENSG00000130449

Symbol
  • KIAA1577
  • AFND
  • NEDMAGA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
virus perturbation
0.83
histone modification site profile
0.74
transcription factor binding site profile
0.73
microRNA
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.64   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.64   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999999469
p_ni:  1e-9
p_wrong:  5.3e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
ALX1
Tbio
Family:  TF
Novelty:  0.01880208
Score:  0.812
Data Source:  STRINGDB
ALX3
Tbio
Family:  TF
Novelty:  0.02711914
Score:  0.81
Data Source:  STRINGDB
ALX4
Tbio
Family:  TF
Novelty:  0.01235474
Score:  0.629
Data Source:  STRINGDB
MIER3
Tdark
Family:  TF
Novelty:  0.42079723
Score:  0.58
Data Source:  STRINGDB
HDGFL1
Tdark
Family:  Epigenetic
Novelty:  0.14333428
Score:  0.577
Data Source:  STRINGDB
KATNB1
Tbio
Novelty:  0.08472625
Score:  0.516
Data Source:  STRINGDB
CCDC15
Tdark
Novelty:  1.32419957
Score:  0.513
Data Source:  STRINGDB
ZNF532
Tdark
Family:  TF
Novelty:  0.32269483
Score:  0.497
Data Source:  STRINGDB
WDPCP
Tbio
Novelty:  0.08368435
Score:  0.493
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
5
92.5
self reported educational attainment
5
5
6
1
92.3
household income
2
8
11
91.5
platelet count
3
3
2
5.1
89.9
10
9
3
1.1
82.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
5
92.5
self reported educational attainment
6
1
92.3
household income
11
91.5
platelet count
2
5.1
89.9
3
1.1
82.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914513
67263
Rat
RGD:1306624
310062
Dog
zinc finger SWIM-type containing 6
VGNC:48859
478068
Horse
zinc finger SWIM-type containing 6
VGNC:25423
100060125
Cow
zinc finger SWIM-type containing 6
VGNC:37386
538841
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
zinc finger SWIM-type containing 6
Horse
zinc finger SWIM-type containing 6
Cow
zinc finger SWIM-type containing 6
Publication Statistics
PubMed Score 9.64
PubMed score by year
PubTator Score 2.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title