Pharos : Target Details

Tbio

Protein Summary

Description

E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.

Uniprot Accession IDs

Gene Name

ZSWIM2

Ensembl ID

ENST00000295131
ENSP00000295131
ENSG00000163012

Symbol

ZZZ2
MEX
ZZZ2

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.74

virus perturbation	0.59

protein domain	0.58

molecular function	0.49

cell line	0.48

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.51 (req: < 5)

View Publications

Gene RIFs: 2 (req: <= 3)

View Gene RIFs

Antibodies: 98 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.51 (req: >= 5)

Gene RIFs: 2 (req: > 3)

Antibodies: 98 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (33)

Explore Interacting Targets

1 – 10 of 33

See Interactions on String-DB

BCAM

Tbio

Novelty: 0.01697541

p_int: 0.999984337

p_ni: 0.000015658

p_wrong: 5e-9

Score: 0.189

Data Source: BioPlex,STRINGDB

TKTL2

Tbio

Family: Enzyme

Novelty: 0.0915871

p_int: 0.9999064

p_ni: 0.0000936

Score: 0.283

Data Source: BioPlex,STRINGDB

SEMG1

Tbio

Novelty: 0.0161449

p_int: 0.997415844

p_ni: 0.002584146

p_wrong: 1e-8

Score: 0.19

Data Source: BioPlex,STRINGDB

LRFN4

Tbio

Novelty: 0.12511571

p_int: 0.989417402

p_ni: 0.010582597

p_wrong: 1e-9

Score: 0.195

Data Source: BioPlex,STRINGDB

RNASE7

Tbio

Family: Enzyme

Novelty: 0.01866347

p_int: 0.953484451

p_ni: 0.046391144

p_wrong: 0.000124404

Data Source: BioPlex

C2orf49

Tbio

Novelty: 0.03911934

Score: 0.836

Data Source: STRINGDB

TRIML1

Tdark

Family: Enzyme

Novelty: 0.63862986

Score: 0.693

Data Source: STRINGDB

EBNA1BP2

Tbio

Novelty: 0.02083466

Score: 0.66

Data Source: STRINGDB

PQLC2

Tbio

Novelty: 0.19332453

Score: 0.632

Data Source: STRINGDB

OXNAD1

Tdark

Family: Enzyme

Novelty: 1.38777329

Score: 0.625

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (3)

Processes (3)

Find Similar Targets

Items per page:

1 – 3 of 3

GO Term	Evidence	Assigned by
protein self-association	Inferred from Electronic Annotation (IEA)	Ensembl

ubiquitin protein ligase activity	Inferred from Electronic Annotation (IEA)	Ensembl

zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (3)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
BMI-adjusted waist circumference	EFO_0007789	1	2	2	26.5

hip circumference	EFO_0005093	1	1	1	3.6

BMI-adjusted waist-hip ratio	EFO_0007788	1	1	1	0.6

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
BMI-adjusted waist circumference	EFO_0007789	2	26.5

hip circumference	EFO_0005093	1	3.6

BMI-adjusted waist-hip ratio	EFO_0007788	1	0.6

Beta Count

Odds Ratio

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UniProt Keyword

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No Header	No Header
3D-structure

Apoptosis

Complete proteome

Metal-binding

Reference proteome

Repeat

Transferase

Ubl conjugation

Ubl conjugation pathway

Zinc

GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID
Chimp	zinc finger SWIM-type containing 2	VGNC:3886	470602

Macaque	zinc finger SWIM-type containing 2		707980

Mouse	zinc finger SWIM-type containing 2	MGI:1919111	71861

Rat	zinc finger, SWIM-type containing 2	RGD:1311373	296455

Dog	zinc finger SWIM-type containing 2	VGNC:48855	478832

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger SWIM-type containing 2

Macaque	zinc finger SWIM-type containing 2

Mouse	zinc finger SWIM-type containing 2

Rat	zinc finger, SWIM-type containing 2

Dog	zinc finger SWIM-type containing 2

Publication Statistics

PubMed Score 63.51

PubMed score by year

PubTator Score 16.08

PubTator score by year

Related Publications

Text Mined References (6)

GeneRif Annotations (2)

Items per page:

0 of 0

PMID	Year	Title