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Tbio
ZSWIM2
E3 ubiquitin-protein ligase ZSWIM2

Protein Summary
Description
E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295131
  • ENSP00000295131
  • ENSG00000163012

Symbol
  • ZZZ2
  • MEX
  • ZZZ2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
virus perturbation
0.59
protein domain
0.58
molecular function
0.49
cell line
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.51   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.51   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
BCAM
Tbio
Novelty:  0.01697541
p_int:  0.999984337
p_ni:  0.000015658
p_wrong:  5e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
TKTL2
Tbio
Family:  Enzyme
Novelty:  0.0915871
p_int:  0.9999064
p_ni:  0.0000936
Score:  0.283
Data Source:  BioPlex,STRINGDB
SEMG1
Tbio
Novelty:  0.0161449
p_int:  0.997415844
p_ni:  0.002584146
p_wrong:  1e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
LRFN4
Tbio
Novelty:  0.12511571
p_int:  0.989417402
p_ni:  0.010582597
p_wrong:  1e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
RNASE7
Tbio
Family:  Enzyme
Novelty:  0.01866347
p_int:  0.953484451
p_ni:  0.046391144
p_wrong:  0.000124404
Data Source:  BioPlex
C2orf49
Tbio
Novelty:  0.03911934
Score:  0.836
Data Source:  STRINGDB
TRIML1
Tdark
Family:  Enzyme
Novelty:  0.63862986
Score:  0.693
Data Source:  STRINGDB
EBNA1BP2
Tbio
Novelty:  0.02083466
Score:  0.66
Data Source:  STRINGDB
PQLC2
Tbio
Novelty:  0.19332453
Score:  0.632
Data Source:  STRINGDB
OXNAD1
Tdark
Family:  Enzyme
Novelty:  1.38777329
Score:  0.625
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
2
2
26.5
hip circumference
1
1
1
3.6
BMI-adjusted waist-hip ratio
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
26.5
hip circumference
1
3.6
BMI-adjusted waist-hip ratio
1
0.6
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger SWIM-type containing 2
VGNC:3886
470602
Macaque
zinc finger SWIM-type containing 2
707980
Mouse
MGI:1919111
71861
Rat
RGD:1311373
296455
Dog
zinc finger SWIM-type containing 2
VGNC:48855
478832
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger SWIM-type containing 2
Macaque
zinc finger SWIM-type containing 2
Mouse
Rat
Dog
zinc finger SWIM-type containing 2
Publication Statistics
PubMed Score 63.51
PubMed score by year
PubTator Score 16.08
PubTator score by year
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Related Publications
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PMID
Year
Title