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Tbio
ZSCAN4
Zinc finger and SCAN domain-containing protein 4

Protein Summary
Description
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318203
  • ENSP00000321963
  • ENSG00000180532
  • ENST00000612521
  • ENSP00000480210

Symbol
  • ZNF494
  • ZNF494
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell line
0.58
small molecule perturbation
0.56
biological process
0.5
cellular component
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.32   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.32   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
DUX4
Tbio
Novelty:  0.00765247
Score:  0.797
Data Source:  STRINGDB
DUX4L7
Tdark
Novelty:  0.00860736
Score:  0.796
Data Source:  STRINGDB
TRIM43
Tdark
Novelty:  0.48246393
Score:  0.687
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.681
Data Source:  STRINGDB
MBD3L2
Tdark
Novelty:  0.2567825
Score:  0.678
Data Source:  STRINGDB
TBX3
Tbio
Family:  TF
Novelty:  0.00515507
Score:  0.678
Data Source:  STRINGDB
PRAMEF2
Tdark
Novelty:  0.63990649
Score:  0.653
Data Source:  STRINGDB
PRAMEF1
Tdark
Novelty:  1.32626817
Score:  0.651
Data Source:  STRINGDB
TERF1
Tbio
Family:  TF
Novelty:  0.00174529
Score:  0.638
Data Source:  STRINGDB
UBTFL1
Tdark
Family:  TF
Novelty:  0.60042165
Score:  0.628
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
4
90.1
mean reticulocyte volume
1
1
1
52.3
1
1
0
1.6
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
90.1
mean reticulocyte volume
1
52.3
0
1.6
5
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and SCAN domain containing 4
VGNC:2115
100612816
Macaque
zinc finger and SCAN domain containing 4
711054
Mouse
MGI:3645954
545913
Mouse
MGI:3645447
665780
Rat
RGD:1309909
299648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and SCAN domain containing 4
Macaque
zinc finger and SCAN domain containing 4
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 54.32
PubMed score by year
PubTator Score 9.03
PubTator score by year
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Related Publications
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PMID
Year
Title