Tdark ZSCAN29 Zinc finger and SCAN domain-containing protein 29

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q8IWY8
• B3KVB9
• Q32M75
• Q32M76
• Q8NA40

Gene Name

• ZSCAN29

Ensembl ID

• ENST00000396976
• ENSP00000380174
• ENSG00000140265

Symbol

• ZNF690
• ZNF690
• Zfp690

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
cell type or tissue	0.69
histone modification site profile	0.67
tissue sample	0.63
cell line	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.54   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.54   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (33)

Explore Interacting Targets

1 – 10 of 33

• See Interactions on String-DB

ZSCAN20

Tdark

Family:  TF

Novelty:  0.37441538

p_int:  0.9999999

p_ni:  9.1e-8

p_wrong:  9e-9

Score:  0.569

Data Source:  BioPlex,STRINGDB

ZNF232

Tdark

Family:  TF

Novelty:  0.68288358

p_int:  0.999995523

p_ni:  0.000004434

p_wrong:  4.3e-8

Score:  0.186

Data Source:  BioPlex,STRINGDB

RPGRIP1L

Tbio

Novelty:  0.00819421

p_int:  0.999867877

p_ni:  0.000132119

p_wrong:  4e-9

Score:  0.252

Data Source:  BioPlex,STRINGDB

EHD2

Tbio

Novelty:  0.02724854

p_int:  0.997582916

p_ni:  0.002417013

p_wrong:  7.1e-8

Score:  0.19

Data Source:  BioPlex,STRINGDB

LRP2

Tbio

Novelty:  0.00143258

p_int:  0.976034089

p_ni:  0.023965911

Score:  0.201

Data Source:  BioPlex,STRINGDB

MAD2L1BP

Tbio

Novelty:  0.48374717

p_int:  0.974338775

p_ni:  0.00070063

p_wrong:  0.024960594

Score:  0.188

Data Source:  BioPlex,STRINGDB

GSDME

Tbio

Novelty:  0.01231123

p_int:  0.93191319

p_ni:  0.067614418

p_wrong:  0.000472393

Score:  0.189

Data Source:  BioPlex,STRINGDB

ABAT

Tclin

Family:  Enzyme

Novelty:  0.0078359

p_int:  0.808496358

p_ni:  0.191503601

p_wrong:  4.1e-8

Score:  0.19

Data Source:  BioPlex,STRINGDB

ZSCAN32

Tdark

Family:  TF

Novelty:  3.83392226

Score:  0.808

Data Source:  STRINGDB

ZNF397

Tbio

Family:  TF

Novelty:  0.60034816

Score:  0.734

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (18)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 18

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	5	2	8		93
hemoglobin measurement	EFO_0004509	2	2	2		92.9
triglyceride measurement	EFO_0004530	5	2	8		92.2
hematocrit	EFO_0004348	2	2	2		91.3
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		81.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	8		93
hemoglobin measurement	EFO_0004509	2		92.9
triglyceride measurement	EFO_0004530	8		92.2
hematocrit	EFO_0004348	2		91.3
apolipoprotein A 1 measurement	EFO_0004614	1		81.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
apolipoprotein A 1 measurement
body weights and measures
C-reactive protein measurement
eosinophil count
eosinophil percentage of leukocytes
follistatin measurement
glycine measurement
hematocrit
hematological measurement

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger and SCAN domain containing 29	VGNC:13465	453377
Macaque	zinc finger and SCAN domain containing 29		710414
Mouse	zinc finger SCAN domains 29	MGI:2139317	99334
Rat	zinc finger SCAN domains 29 [Source:MGI Symbol;Acc:MGI:2139317]
Dog	zinc finger and SCAN domain containing 29	VGNC:48853	100856740

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger and SCAN domain containing 29
Macaque	zinc finger and SCAN domain containing 29
Mouse	zinc finger SCAN domains 29
Rat	zinc finger SCAN domains 29 [Source:MGI Symbol;Acc:MGI:2139317]
Dog	zinc finger and SCAN domain containing 29

Publication Statistics

PubMed Score 0.54

PubMed score by year

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PubTator Score 0.28

PubTator score by year

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Related Publications

Text Mined References (5)

Items per page:

10

0 of 0

PMID	Year	Title