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Tbio
ZRANB2
Zinc finger Ran-binding domain-containing protein 2

Protein Summary
Description
Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254821
  • ENSP00000254821
  • ENSG00000132485
  • ENST00000370920
  • ENSP00000359958
  • ENST00000611683
  • ENSP00000482026

Symbol
  • ZIS
  • ZNF265
  • ZIS
  • ZIS1
  • ZIS2
  • ZNF265
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.99
interacting protein
0.91
drug perturbation
0.87
transcription factor binding site profile
0.85
small molecule perturbation
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.76   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.76   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.696
Data Source:  BioPlex,STRINGDB
NFKBIL1
Tbio
Novelty:  0.03932489
p_int:  0.999997314
p_ni:  0.000002685
Score:  0.696
Data Source:  BioPlex,STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.999892775
p_ni:  0.000107225
Data Source:  BioPlex
PIP4K2B
Tchem
Family:  Kinase
Novelty:  0.06261627
p_int:  0.999362946
p_ni:  0.000637054
Score:  0.696
Data Source:  BioPlex,STRINGDB
SREK1
Tbio
Novelty:  0.19228162
p_int:  0.999307745
p_ni:  0.000692255
Score:  0.727
Data Source:  BioPlex,STRINGDB
PIP4K2C
Tchem
Family:  Kinase
Novelty:  0.11466436
p_int:  0.9991468
p_ni:  0.000853199
Score:  0.594
Data Source:  BioPlex,STRINGDB
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
p_int:  0.994896637
p_ni:  0.005103363
p_wrong:  1e-9
Data Source:  BioPlex
EPB41L2
Tbio
Novelty:  0.0311733
p_int:  0.993752907
p_ni:  0.006247093
Data Source:  BioPlex
TOP1
Tclin
Family:  Enzyme
Novelty:  0.00019573
p_int:  0.992838763
p_ni:  0.007161237
Score:  0.556
Data Source:  BioPlex,STRINGDB
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.991515868
p_ni:  0.008484132
Score:  0.226
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
4
4
4
71.9
smoking status measurement
2
1
2
54.4
body height
1
1
1
42.3
self reported educational attainment
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
4
71.9
smoking status measurement
2
54.4
body height
1
42.3
self reported educational attainment
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger RANBP2-type containing 2
VGNC:8143
744970
Macaque
zinc finger RANBP2-type containing 2
703513
Mouse
MGI:1858211
53861
Rat
RGD:61854
58821
Dog
zinc finger RANBP2-type containing 2
VGNC:48848
490213
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger RANBP2-type containing 2
Macaque
zinc finger RANBP2-type containing 2
Mouse
Rat
Dog
zinc finger RANBP2-type containing 2
Publication Statistics
PubMed Score 19.76
PubMed score by year
PubTator Score 18.44
PubTator score by year
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Related Publications
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PMID
Year
Title