Tbio ZPLD1 Zona pellucida-like domain-containing protein 1

Protein Summary

Description

Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ.

Uniprot Accession IDs

• Q8TCW7
• Q49AS1
• Q8WU36
• ZP domain-containing protein 1

Gene Name

• ZPLD1

Ensembl ID

• ENST00000306176
• ENSP00000307801
• ENSG00000170044
• ENST00000466937
• ENSP00000418253
• ENST00000491959
• ENSP00000420265

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.58
cell type or tissue	0.43
cell line	0.41
disease	0.35
biological term	0.34

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.13   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.13   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (29)

Explore Interacting Targets

1 – 10 of 29

• See Interactions on String-DB

CEACAM8

Tbio

Novelty:  0.00370138

p_int:  0.999988279

p_ni:  0.00001172

p_wrong:  1e-9

Score:  0.371

Data Source:  BioPlex,STRINGDB

RARG

Tclin

Family:  NR

Novelty:  0.00667159

p_int:  0.999937573

p_ni:  0.000062422

p_wrong:  5e-9

Score:  0.187

Data Source:  BioPlex,STRINGDB

GNPTAB

Tbio

Family:  Enzyme

Novelty:  0.00336101

p_int:  0.998720372

p_ni:  0.001279627

Score:  0.552

Data Source:  BioPlex,STRINGDB

CARMIL1

Tbio

Novelty:  0.04162135

p_int:  0.998638231

p_ni:  0.001361531

p_wrong:  2.37e-7

Score:  0.232

Data Source:  BioPlex,STRINGDB

RTN4

Tbio

Novelty:  0.00080371

p_int:  0.996221393

p_ni:  0.003778607

Data Source:  BioPlex

TMX1

Tbio

Novelty:  0.03444237

p_int:  0.963710298

p_ni:  0.036289702

Data Source:  BioPlex

SDF2L1

Tbio

Novelty:  0.12184663

p_int:  0.943360165

p_ni:  0.056639835

Score:  0.183

Data Source:  BioPlex,STRINGDB

STEAP2

Tbio

Family:  Enzyme

Novelty:  0.02727622

p_int:  0.911748057

p_ni:  0.00002589

p_wrong:  0.088226053

Score:  0.282

Data Source:  BioPlex,STRINGDB

GNPTG

Tbio

Family:  Enzyme

Novelty:  0.03345886

p_int:  0.783861446

p_ni:  0.216138541

p_wrong:  1.3e-8

Score:  0.806

Data Source:  BioPlex,STRINGDB

FAM207A

Tdark

Novelty:  0.62803282

p_int:  0.76070839

p_ni:  0.239291609

Score:  0.188

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Components (3)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
cytoplasmic vesicle membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
extracellular region	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	2	1	2		58.4
multiple sclerosis	EFO_0003885	2	2	0	1.1	34.7
C-reactive protein measurement	EFO_0004458	1	1	1		26.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	2		58.4
multiple sclerosis	EFO_0003885	0	1.1	34.7
C-reactive protein measurement	EFO_0004458	1		26.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytoplasmic vesicle
Disulfide bond
Extracellular matrix
Glycoprotein
Membrane
Polymorphism
Reference proteome
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
C-reactive protein measurement
multiple sclerosis

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zona pellucida like domain containing 1	VGNC:13011	470875
Macaque	zona pellucida like domain containing 1		703200
Mouse	zona pellucida like domain containing 1	MGI:2443415	239852
Rat	zona pellucida-like domain containing 1	RGD:1308138	363768
Dog	zona pellucida like domain containing 1	VGNC:48845	487958

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zona pellucida like domain containing 1
Macaque	zona pellucida like domain containing 1
Mouse	zona pellucida like domain containing 1
Rat	zona pellucida-like domain containing 1
Dog	zona pellucida like domain containing 1

Publication Statistics

PubMed Score 6.13

PubMed score by year

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PubTator Score 5.28

PubTator score by year

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Related Publications

Text Mined References (7)

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Year	Title