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Tbio
ZPLD1
Zona pellucida-like domain-containing protein 1

Protein Summary
Description
Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306176
  • ENSP00000307801
  • ENSG00000170044
  • ENST00000466937
  • ENSP00000418253
  • ENST00000491959
  • ENSP00000420265
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.58
cell type or tissue
0.43
cell line
0.41
disease
0.35
biological term
0.34


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.13   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.13   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
CEACAM8
Tbio
Novelty:  0.00370138
p_int:  0.999988279
p_ni:  0.00001172
p_wrong:  1e-9
Score:  0.371
Data Source:  BioPlex,STRINGDB
RARG
Tclin
Family:  NR
Novelty:  0.00667159
p_int:  0.999937573
p_ni:  0.000062422
p_wrong:  5e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
GNPTAB
Tbio
Family:  Enzyme
Novelty:  0.00336101
p_int:  0.998720372
p_ni:  0.001279627
Score:  0.552
Data Source:  BioPlex,STRINGDB
CARMIL1
Tbio
Novelty:  0.04162135
p_int:  0.998638231
p_ni:  0.001361531
p_wrong:  2.37e-7
Score:  0.232
Data Source:  BioPlex,STRINGDB
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.996221393
p_ni:  0.003778607
Data Source:  BioPlex
TMX1
Tbio
Novelty:  0.03444237
p_int:  0.963710298
p_ni:  0.036289702
Data Source:  BioPlex
SDF2L1
Tbio
Novelty:  0.12184663
p_int:  0.943360165
p_ni:  0.056639835
Score:  0.183
Data Source:  BioPlex,STRINGDB
STEAP2
Tbio
Family:  Enzyme
Novelty:  0.02727622
p_int:  0.911748057
p_ni:  0.00002589
p_wrong:  0.088226053
Score:  0.282
Data Source:  BioPlex,STRINGDB
GNPTG
Tbio
Family:  Enzyme
Novelty:  0.03345886
p_int:  0.783861446
p_ni:  0.216138541
p_wrong:  1.3e-8
Score:  0.806
Data Source:  BioPlex,STRINGDB
FAM207A
Tdark
Novelty:  0.62803282
p_int:  0.76070839
p_ni:  0.239291609
Score:  0.188
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
1
2
58.4
2
2
0
1.1
34.7
C-reactive protein measurement
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
58.4
0
1.1
34.7
C-reactive protein measurement
1
26.6
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zona pellucida like domain containing 1
VGNC:13011
470875
Macaque
zona pellucida like domain containing 1
703200
Mouse
MGI:2443415
239852
Rat
RGD:1308138
363768
Dog
zona pellucida like domain containing 1
VGNC:48845
487958
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zona pellucida like domain containing 1
Macaque
zona pellucida like domain containing 1
Mouse
Rat
Dog
zona pellucida like domain containing 1
Publication Statistics
PubMed Score 6.13
PubMed score by year
PubTator Score 5.28
PubTator score by year
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Related Publications
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PMID
Year
Title