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Tbio
ZPBP2
Zona pellucida-binding protein 2

Protein Summary
Description
Is implicated in sperm-oocyte interaction during fertilization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348931
  • ENSP00000335384
  • ENSG00000186075
  • ENST00000377940
  • ENSP00000367174

Symbol
  • ZPBPL
  • ZPBPL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
cell line
0.68
transcription factor
0.65
disease
0.52
PubMedID
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.89   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.89   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
PPP1R1A
Tbio
Family:  Enzyme
Novelty:  0.01565981
p_int:  0.999942241
p_ni:  0.000043562
p_wrong:  0.000014197
Score:  0.188
Data Source:  BioPlex,STRINGDB
ZNF146
Tbio
Family:  TF
Novelty:  0.05977172
p_int:  0.995939066
p_ni:  0.002963311
p_wrong:  0.001097622
Score:  0.189
Data Source:  BioPlex,STRINGDB
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.955537065
p_ni:  0.04446293
p_wrong:  5e-9
Data Source:  BioPlex
OS9
Tbio
Novelty:  0.01490339
p_int:  0.89346057
p_ni:  0.10653943
Data Source:  BioPlex
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.874520616
p_ni:  0.125479384
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.858517112
p_ni:  0.141482887
Data Source:  BioPlex
FSTL1
Tbio
Novelty:  0.00557848
p_int:  0.821457315
p_ni:  0.13283531
p_wrong:  0.045707375
Data Source:  BioPlex
PROS1
Tbio
Novelty:  0.00275184
p_int:  0.776042871
p_ni:  0.223957129
Score:  0.295
Data Source:  BioPlex,STRINGDB
SEL1L
Tbio
Novelty:  0.01198173
p_int:  0.754432838
p_ni:  0.245567162
Score:  0.22
Data Source:  BioPlex,STRINGDB
GSDMB
Tbio
Novelty:  0.01979674
Score:  0.836
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (49)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
5
7
0
1.3
99.8
asthma
18
17
3
1.2
99.8
primary biliary cirrhosis
6
5
2
1.4
99.1
age at onset
3
6
2
1.2
98.7
allergic disease
6
4
4
1.1
97.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1.3
99.8
asthma
3
1.2
99.8
primary biliary cirrhosis
2
1.4
99.1
age at onset
2
1.2
98.7
allergic disease
4
1.1
97.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zona pellucida binding protein 2
VGNC:9809
454638
Macaque
zona pellucida binding protein 2
698217
Mouse
MGI:1916626
69376
Rat
RGD:1549726
363676
Horse
zona pellucida binding protein 2
VGNC:25407
100068017
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zona pellucida binding protein 2
Macaque
zona pellucida binding protein 2
Mouse
Rat
Horse
zona pellucida binding protein 2
Publication Statistics
PubMed Score 16.89
PubMed score by year
PubTator Score 10.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title