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Tbio
ZP2
Zona pellucida sperm-binding protein 2

Protein Summary
Description
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000574002
  • ENSP00000460971
  • ENSG00000103310
  • ENST00000574091
  • ENSP00000458991
  • ENST00000638300
  • ENSP00000492703
  • ENSG00000284588
  • ENST00000640487
  • ENSP00000491583

Symbol
  • ZPA
  • ZPA
  • Zp-2
  • OOMD6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.89
co-expressed gene
0.87
cellular component
0.56
tissue
0.52
cell line
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.89   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.89   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.999970834
p_ni:  0.000029166
Data Source:  BioPlex
EXT1
Tbio
Family:  Enzyme
Novelty:  0.00355951
p_int:  0.999913297
p_ni:  0.000085941
p_wrong:  7.62e-7
Data Source:  BioPlex
RHOBTB3
Tbio
Novelty:  0.09149494
p_int:  0.989776008
p_ni:  0.009008907
p_wrong:  0.001215085
Data Source:  BioPlex
INTS7
Tdark
Novelty:  0.04592325
p_int:  0.962973302
p_ni:  0.037026546
p_wrong:  1.52e-7
Data Source:  BioPlex
FAR2
Tbio
Family:  Enzyme
Novelty:  0.05384036
p_int:  0.960195436
p_ni:  0.039804515
p_wrong:  4.9e-8
Data Source:  BioPlex
HPCAL1
Tbio
Novelty:  0.04434155
p_int:  0.945110325
p_ni:  0.054839378
p_wrong:  0.000050297
Data Source:  BioPlex
TSC2
Tbio
Novelty:  0.00067416
p_int:  0.871870999
p_ni:  0.128129001
Data Source:  BioPlex
BCKDHB
Tbio
Family:  Enzyme
Novelty:  0.02234969
p_int:  0.821666866
p_ni:  0.178331969
p_wrong:  0.000001165
Data Source:  BioPlex
ZP3
Tbio
Novelty:  0.00140352
Score:  0.943
Data Source:  STRINGDB
ADAM2
Tbio
Family:  Enzyme
Novelty:  0.00586482
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Interaction With Cumulus Cells And The Zona Pellucida
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Fertilization
Interaction With Cumulus Cells And The Zona Pellucida
Reproduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zona pellucida glycoprotein 2
697458
Mouse
MGI:99214
22787
Rat
RGD:620605
81828
Dog
zona pellucida glycoprotein 2
VGNC:48842
403988
Horse
zona pellucida glycoprotein 2
VGNC:25404
100059065
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zona pellucida glycoprotein 2
Mouse
Rat
Dog
zona pellucida glycoprotein 2
Horse
zona pellucida glycoprotein 2
Publication Statistics
PubMed Score 336.89
PubMed score by year
PubTator Score 76.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title