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Tbio
ZNRF4
E3 ubiquitin-protein ligase ZNRF4

Protein Summary
Description
E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830). Could have a role in spermatogenesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222033
  • ENSP00000222033
  • ENSG00000105428

Symbol
  • RNF204
  • spzn
  • RNF204
  • Ssrzf1
  • SPERIZIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
cell type or tissue
0.61
PubMedID
0.58
tissue
0.53
disease perturbation
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
UBA52
Tbio
Novelty:  0.01637744
p_int:  0.999999959
p_ni:  9e-9
p_wrong:  3.2e-8
Data Source:  BioPlex
DAGLA
Tchem
Family:  Enzyme
Novelty:  0.00959313
p_int:  0.999998893
p_ni:  6.52e-7
p_wrong:  4.56e-7
Score:  0.185
Data Source:  BioPlex,STRINGDB
ABCA2
Tbio
Family:  Transporter
Novelty:  0.02208136
p_int:  0.999975542
p_ni:  0.000024454
p_wrong:  4e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
AREL1
Tdark
Family:  Enzyme
Novelty:  0.31082841
p_int:  0.999954369
p_ni:  0.000045621
p_wrong:  1e-8
Score:  0.16
Data Source:  BioPlex,STRINGDB
FZD6
Tbio
Family:  GPCR
Novelty:  0.01425136
p_int:  0.999938907
p_ni:  0.000061066
p_wrong:  2.6e-8
Data Source:  BioPlex
PDZD8
Tbio
Novelty:  0.09015543
p_int:  0.999899569
p_ni:  0.000100431
Data Source:  BioPlex
KCNT2
Tchem
Family:  IC
Novelty:  0.02412039
p_int:  0.99988232
p_ni:  0.00011768
Data Source:  BioPlex
KCNG1
Tclin
Family:  IC
Novelty:  0.0089612
p_int:  0.9997112
p_ni:  0.000087522
p_wrong:  0.000201277
Score:  0.173
Data Source:  BioPlex,STRINGDB
ST7L
Tbio
Novelty:  0.03661324
p_int:  0.999442367
p_ni:  0.000557633
Data Source:  BioPlex
ADCK2
Tbio
Family:  Kinase
Novelty:  0.13237052
p_int:  0.999172143
p_ni:  0.000827856
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
2
2
45.7
mitochondrial heteroplasmy measurement
1
1
1
14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
2
45.7
mitochondrial heteroplasmy measurement
1
14
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc and ring finger 4
695996
Mouse
MGI:1341258
20834
Rat
RGD:1563631
301127
Dog
zinc and ring finger 4
VGNC:48841
485029
Cow
zinc and ring finger 4
VGNC:37365
517394
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc and ring finger 4
Mouse
Rat
Dog
zinc and ring finger 4
Cow
zinc and ring finger 4
Publication Statistics
PubMed Score 6.43
PubMed score by year
PubTator Score 2.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title