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Tbio
ZNRF1
E3 ubiquitin-protein ligase ZNRF1

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable). This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320619
  • ENSP00000323362
  • ENSG00000186187
  • ENST00000335325
  • ENSP00000335091
  • ENST00000567962
  • ENSP00000455601

Symbol
  • NIN283
  • NIN283
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor binding site profile
0.91
kinase perturbation
0.84
transcription factor perturbation
0.8
transcription factor
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.26   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.26   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (270)
FBXW5
Tbio
Novelty:  0.13100873
p_int:  0.999824536
p_ni:  0.000175444
p_wrong:  2e-8
Score:  0.917
Data Source:  BioPlex,STRINGDB
NMT2
Tchem
Family:  Enzyme
Novelty:  0.04826835
p_int:  0.869125984
p_ni:  0.130874005
p_wrong:  1.1e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
TSEN2
Tbio
Family:  Enzyme
Novelty:  0.04151213
p_int:  0.81716544
p_ni:  0.182834558
p_wrong:  2e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.770698173
p_ni:  0.024142626
p_wrong:  0.205159201
Score:  0.209
Data Source:  BioPlex,STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.997
Data Source:  STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.989
Data Source:  STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.978
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.966
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.965
Data Source:  STRINGDB
UBE2E1
Tbio
Novelty:  0.04048768
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
3
2
2
1.2
90.3
type 1 diabetes mellitus
2
2
1
1.3
90.3
blood protein measurement
4
3
4
87.9
lymphocyte count
3
2
3
68.4
1
1
0
1.4
49.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
1.2
90.3
type 1 diabetes mellitus
1
1.3
90.3
blood protein measurement
4
87.9
lymphocyte count
3
68.4
0
1.4
49.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc and ring finger 1
VGNC:51239
736544
Macaque
zinc and ring finger 1
710762
Mouse
MGI:2177308
170737
Rat
RGD:1592195
690769
Dog
zinc and ring finger 1
VGNC:48839
100687514
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc and ring finger 1
Macaque
zinc and ring finger 1
Mouse
Rat
Dog
zinc and ring finger 1
Publication Statistics
PubMed Score 10.26
PubMed score by year
PubTator Score 4.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title