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Tbio
ZNHIT1
Zinc finger HIT domain-containing protein 1

Protein Summary
Description
Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305105
  • ENSP00000304593
  • ENSG00000106400

Symbol
  • CGBP1
  • ZNFN4A1
  • CG1I
  • ZNFN4A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
histone modification site profile
0.91
kinase perturbation
0.88
transcription factor perturbation
0.68
gene perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.81   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.81   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0