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Tbio
ZNHIT1
Zinc finger HIT domain-containing protein 1

Protein Summary
Description
Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305105
  • ENSP00000304593
  • ENSG00000106400

Symbol
  • CGBP1
  • ZNFN4A1
  • CG1I
  • ZNFN4A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
histone modification site profile
0.91
kinase perturbation
0.88
transcription factor perturbation
0.68
gene perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.33   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.33   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
VPS72
Tbio
Novelty:  0.00561093
p_int:  0.999999864
p_ni:  1.36e-7
Score:  0.93
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999999673
p_ni:  3.08e-7
p_wrong:  1.9e-8
Score:  0.638
Data Source:  BioPlex,STRINGDB
SRCAP
Tbio
Family:  Enzyme
Novelty:  0.02446238
p_int:  0.99999605
p_ni:  0.00000395
Score:  0.954
Data Source:  BioPlex,STRINGDB
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
p_int:  0.999990999
p_ni:  0.000008949
p_wrong:  5.3e-8
Score:  0.756
Data Source:  BioPlex,STRINGDB
ACTR6
Tbio
Novelty:  0.11005766
p_int:  0.999919739
p_ni:  0.000014006
p_wrong:  0.000066256
Score:  0.955
Data Source:  BioPlex,STRINGDB
ACTL6B
Tbio
Novelty:  0.05740204
p_int:  0.999899194
p_ni:  0.000100806
Score:  0.486
Data Source:  BioPlex,STRINGDB
YEATS4
Tbio
Novelty:  0.02632024
p_int:  0.99977796
p_ni:  0.000221973
p_wrong:  6.8e-8
Score:  0.87
Data Source:  BioPlex,STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.999655957
p_ni:  0.00034345
p_wrong:  5.93e-7
Score:  0.647
Data Source:  BioPlex,STRINGDB
KDM5C
Tchem
Family:  TF; Epigenetic
Novelty:  0.00701855
p_int:  0.999041299
p_ni:  0.000958695
p_wrong:  6e-9
Data Source:  BioPlex
NFATC2IP
Tbio
Novelty:  0.02974299
p_int:  0.997382461
p_ni:  0.000110888
p_wrong:  0.002506651
Score:  0.82
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
81.5
lymphocyte count
1
1
1
53.3
body mass index
1
1
1
44.2
plasminogen activator inhibitor 1 measurement
1
1
1
38.7
body height
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
81.5
lymphocyte count
1
53.3
body mass index
1
44.2
plasminogen activator inhibitor 1 measurement
1
38.7
body height
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger HIT-type containing 1
VGNC:4589
472469
Macaque
zinc finger HIT-type containing 1
714339
Mouse
MGI:1917353
70103
Rat
RGD:2322870
100360077
Dog
zinc finger HIT-type containing 1
VGNC:48835
479729
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger HIT-type containing 1
Macaque
zinc finger HIT-type containing 1
Mouse
Rat
Dog
zinc finger HIT-type containing 1
Publication Statistics
PubMed Score 253.33
PubMed score by year
PubTator Score 1.20
PubTator score by year
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Related Publications
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PMID
Year
Title