You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
ZNF821
Zinc finger protein 821

Protein Summary
Description
May be involved in transcriptional regulation. This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000425432
  • ENSP00000398089
  • ENSG00000102984
  • ENST00000565601
  • ENSP00000455648
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.62
disease perturbation
0.56
histone modification site profile
0.56
gene perturbation
0.55
transcription factor binding site profile
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
ATXN1L
Tbio
Novelty:  0.1105313
Score:  0.742
Data Source:  STRINGDB
TXNL4B
Tbio
Novelty:  0.00695407
Score:  0.717
Data Source:  STRINGDB
IST1
Tbio
Novelty:  0.01780503
Score:  0.71
Data Source:  STRINGDB
DHX38
Tbio
Family:  Enzyme
Novelty:  0.01939445
Score:  0.698
Data Source:  STRINGDB
PMFBP1
Tbio
Novelty:  0.25081073
Score:  0.619
Data Source:  STRINGDB
ELK3
Tbio
Family:  TF
Novelty:  0.47338659
Score:  0.581
Data Source:  STRINGDB
MTHFSD
Tdark
Family:  Enzyme
Novelty:  0.2764448
Score:  0.572
Data Source:  STRINGDB
AP1G1
Tbio
Novelty:  0.03754132
Score:  0.572
Data Source:  STRINGDB
ZNF414
Tdark
Novelty:  1.29024829
Score:  0.522
Data Source:  STRINGDB
MARVELD3
Tbio
Novelty:  0.10486289
Score:  0.52
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
8
8
96.1
total cholesterol measurement
3
9
9
95.6
apolipoprotein B measurement
2
8
8
93
intelligence
3
5
2
6
83
educational attainment
1
2
2
79.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
96.1
total cholesterol measurement
9
95.6
apolipoprotein B measurement
8
93
intelligence
2
6
83
educational attainment
2
79.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 821
VGNC:5973
468020
Macaque
zinc finger protein 821
707355
Mouse
MGI:1923121
75871
Rat
RGD:1306674
307834
Dog
zinc finger protein 821
VGNC:48827
489726
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 821
Macaque
zinc finger protein 821
Mouse
Rat
Dog
zinc finger protein 821
Publication Statistics
PubMed Score 2.07
PubMed score by year
PubTator Score 1.14
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title