Tdark ZNF800 Zinc finger protein 800

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q2TB10
• Q9HBN0

Gene Name

• ZNF800

Ensembl ID

• ENST00000265827
• ENSP00000265827
• ENSG00000048405
• ENST00000393312
• ENSP00000376988
• ENST00000393313
• ENSP00000376989

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
transcription factor perturbation	0.74
microRNA	0.73
transcription factor binding site profile	0.7
tissue sample	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.8   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.8   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (26)

Explore Interacting Targets

1 – 10 of 26

• See Interactions on String-DB

RRP8

Tbio

Family:  Enzyme

Novelty:  0.04922797

p_int:  0.998692513

p_ni:  0.001307467

p_wrong:  2e-8

Score:  0.514

Data Source:  BioPlex,STRINGDB

PRR11

Tbio

Novelty:  0.05077483

p_int:  0.995697892

p_ni:  0.004297225

p_wrong:  0.000004884

Data Source:  BioPlex

ZNF2

Tbio

Family:  TF

Novelty:  0.01062543

p_int:  0.990880889

p_ni:  0.009110318

p_wrong:  0.000008793

Data Source:  BioPlex

NPM1

Tbio

Novelty:  0.0005485

p_int:  0.988505991

p_ni:  0.011494009

Score:  0.156

Data Source:  BioPlex,STRINGDB

MECP2

Tchem

Family:  TF

Novelty:  0.00051767

p_int:  0.987421459

p_ni:  0.012557177

p_wrong:  0.000021364

Data Source:  BioPlex

HDAC1

Tclin

Family:  Epigenetic

Novelty:  0.00065244

p_int:  0.984690888

p_ni:  0.015309112

Score:  0.28

Data Source:  BioPlex,STRINGDB

DGCR8

Tbio

Novelty:  0.00271221

p_int:  0.983937671

p_ni:  0.016041329

p_wrong:  0.000021

Data Source:  BioPlex

MTA2

Tbio

Family:  TF

Novelty:  0.01525806

p_int:  0.969843783

p_ni:  0.030156217

Score:  0.315

Data Source:  BioPlex,STRINGDB

MTA3

Tbio

Family:  TF

Novelty:  0.02667635

p_int:  0.963358888

p_ni:  0.036641111

p_wrong:  1e-9

Score:  0.666

Data Source:  BioPlex,STRINGDB

CNBP

Tbio

Novelty:  0.00404247

p_int:  0.945789036

p_ni:  0.005080793

p_wrong:  0.049130171

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (19)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	2	5		92.4
type II diabetes mellitus	EFO_0001360	2	2	1	1.1	83.8
red blood cell distribution width	EFO_0005192	2	2	2		82.9
lymphocyte percentage of leukocytes	EFO_0007993	1	2	2		81.2
appendicular lean mass	EFO_0004980	4	1	4		78.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 19

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	5		92.4
type II diabetes mellitus	EFO_0001360	1	1.1	83.8
red blood cell distribution width	EFO_0005192	2		82.9
lymphocyte percentage of leukocytes	EFO_0007993	2		81.2
appendicular lean mass	EFO_0004980	4		78.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
BMI-adjusted leptin measurement
cataract
cognitive function measurement
heel bone mineral density
intelligence
low density lipoprotein cholesterol measurement
lymphocyte count
lymphocyte percentage of leukocytes
neuroticism measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 800	VGNC:4586	463695
Macaque	zinc finger protein 800		697855
Mouse	zinc finger protein 800	MGI:1889334	627049
Rat	zinc finger protein 800	RGD:1560157	500057
Dog	zinc finger protein 800	VGNC:48823	475207

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 800
Macaque	zinc finger protein 800
Mouse	zinc finger protein 800
Rat	zinc finger protein 800
Dog	zinc finger protein 800

Publication Statistics

PubMed Score 2.80

PubMed score by year

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PubTator Score 0.50

PubTator score by year

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Related Publications

Text Mined References (5)

Items per page:

10

0 of 0

PMID	Year	Title