Tdark ZNF764 Zinc finger protein 764

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q96H86
• A8MZF4
• B3KSN2
• H9KV99
• Q9BWS1

Gene Name

• ZNF764

Ensembl ID

• ENST00000252797
• ENSP00000252797
• ENSG00000169951
• ENST00000395091
• ENSP00000378526

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
cell type or tissue	0.61
histone modification site profile	0.61
protein domain	0.58
transcription factor binding site profile	0.56

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein 764

Protein / ... / Krab Box Transcription Factor / Zinc Finger Protein 764

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Zinc Finger Protein 764

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.11   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.11   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (39)

Explore Interacting Targets

1 – 10 of 39

• See Interactions on String-DB

SH3PXD2A

Tbio

Novelty:  0.0252753

p_int:  1

Score:  0.37

Data Source:  BioPlex,STRINGDB

NEBL

Tbio

Novelty:  0.02155964

p_int:  1

Score:  0.161

Data Source:  BioPlex,STRINGDB

SUFU

Tbio

Novelty:  0.00475249

p_int:  0.999999616

p_ni:  3.83e-7

Score:  0.28

Data Source:  BioPlex,STRINGDB

VWCE

Tbio

Novelty:  0.09328341

p_int:  0.999998336

p_ni:  0.000001487

p_wrong:  1.77e-7

Data Source:  BioPlex

SH3PXD2B

Tbio

Novelty:  0.04207866

p_int:  0.999996907

p_ni:  0.000003093

Score:  0.225

Data Source:  BioPlex,STRINGDB

TRIM39

Tbio

Family:  Enzyme

Novelty:  0.0837441

p_int:  0.999995477

p_ni:  0.000004523

Score:  0.154

Data Source:  BioPlex,STRINGDB

GTF3C4

Tdark

Family:  Epigenetic

Novelty:  0.28198123

p_int:  0.999994652

p_ni:  0.00000534

p_wrong:  8e-9

Data Source:  BioPlex

USP34

Tbio

Family:  Enzyme

Novelty:  0.16444192

p_int:  0.999931352

p_ni:  0.000068648

Score:  0.198

Data Source:  BioPlex,STRINGDB

GNE

Tbio

Family:  Enzyme

Novelty:  0.00285751

p_int:  0.999767485

p_ni:  0.0002325

p_wrong:  1.6e-8

Score:  0.161

Data Source:  BioPlex,STRINGDB

SMARCAD1

Tbio

Novelty:  0.04117162

p_int:  0.99952187

p_ni:  0.000478073

p_wrong:  5.7e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (15)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 15

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3	3	4		96.9
myeloid white cell count	EFO_0007988	2	2	2		94.8
leukocyte count	EFO_0004308	2	2	2		90
lymphocyte percentage of leukocytes	EFO_0007993	2	2	2		85.7
neutrophil count	EFO_0004833	2	2	2		82.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 15

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	4		96.9
myeloid white cell count	EFO_0007988	2		94.8
leukocyte count	EFO_0004308	2		90
lymphocyte percentage of leukocytes	EFO_0007993	2		85.7
neutrophil count	EFO_0004833	2		82.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
DNA-binding
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
basophil count
eosinophil count
heel bone mineral density
leukocyte count
lymphocyte count
lymphocyte percentage of leukocytes
monocyte count
myeloid white cell count
neutrophil count

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	zinc finger protein 747	MGI:2443581	269997
Mouse	RIKEN cDNA 9130019O22 gene	MGI:1926171	78921
Rat	KRAB domain-containing protein ZNF747-like	RGD:7731019	102553962
Horse	zinc finger protein 764		102149734

Species	Name	OMA	EggNOG	Inparanoid
Mouse	zinc finger protein 747
Mouse	RIKEN cDNA 9130019O22 gene
Rat	KRAB domain-containing protein ZNF747-like
Horse	zinc finger protein 764

Publication Statistics

PubMed Score 2.11

PubMed score by year

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PubTator Score 1.00

PubTator score by year

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Related Publications

Text Mined References (5)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title