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Tbio
ZNF74
Zinc finger protein 74

Protein Summary
Description
May play a role in RNA metabolism.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400451
  • ENSP00000383301
  • ENSG00000185252
  • ENST00000403682
  • ENSP00000384750
  • ENST00000405993
  • ENSP00000385855
  • ENST00000611540
  • ENSP00000483077

Symbol
  • ZNF520
  • COS52
  • hZNF7
  • ZFP520
  • ZNF520
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.7
histone modification site profile
0.69
protein domain
0.58
small molecule perturbation
0.58
cellular component
0.5


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.66   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.66   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
TNNC2
Tbio
Novelty:  0.07759506
p_int:  0.999999826
p_ni:  1.68e-7
p_wrong:  6e-9
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999994669
p_ni:  0.000005325
p_wrong:  6e-9
Data Source:  BioPlex
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.999986352
p_ni:  5.7e-8
p_wrong:  0.000013592
Score:  0.251
Data Source:  BioPlex,STRINGDB
DVL1
Tchem
Novelty:  0.00356876
p_int:  0.999417199
p_ni:  3.6e-8
p_wrong:  0.000582765
Data Source:  BioPlex
KIF7
Tbio
Novelty:  0.02734596
p_int:  0.999021435
p_ni:  0.000978563
p_wrong:  1e-9
Data Source:  BioPlex
P3H2
Tbio
Family:  Enzyme
Novelty:  0.04237396
p_int:  0.998874713
p_ni:  0.000408874
p_wrong:  0.000716414
Data Source:  BioPlex
RBAK
Tbio
Family:  TF
Novelty:  0.12597665
p_int:  0.997692466
p_ni:  0.00170427
p_wrong:  0.000603264
Data Source:  BioPlex
FBXO11
Tbio
Novelty:  0.02762674
p_int:  0.995927583
p_ni:  0.004072417
Data Source:  BioPlex
SNX18
Tbio
Novelty:  0.10461787
p_int:  0.995709324
p_ni:  0.004263827
p_wrong:  0.000026849
Data Source:  BioPlex
TCEAL5
Tdark
Novelty:  1.78893063
p_int:  0.995493456
p_ni:  0.000157776
p_wrong:  0.004348768
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
2
3
91.6
forced expiratory volume
2
2
2
58.5
brain measurement
1
1
0
7.6
50.5
appendicular lean mass
1
1
1
18.9
balding measurement
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
3
91.6
forced expiratory volume
2
58.5
brain measurement
0
7.6
50.5
appendicular lean mass
1
18.9
balding measurement
1
11.2
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 74
693891
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 74
Publication Statistics
PubMed Score 10.66
PubMed score by year
PubTator Score 9.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title