Tdark ZNF735 Putative zinc finger protein 735

Protein Summary

Description

May be involved in transcriptional regulation. This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and nine C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]

Uniprot Accession IDs

• P0CB33

Gene Name

• ZNF735

Ensembl ID

• ENST00000429565
• ENSP00000485547
• ENSG00000223614

Symbol

• ZNF735P
• ZNF735P

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.58
protein domain	0.58
biological process	0.41
disease	0.41
phenotype	0.36

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.1   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.1   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0