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Tbio
ZNF687
Zinc finger protein 687

Protein Summary
Description
May be involved in transcriptional regulation. This gene encodes C2H2 zinc finger protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324048
  • ENSP00000319829
  • ENSG00000143373
  • ENST00000336715
  • ENSP00000336620

Symbol
  • KIAA1441
  • PDB6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor
0.85
histone modification site profile
0.78
drug perturbation
0.71
cell type or tissue
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.999999514
p_ni:  4.86e-7
Data Source:  BioPlex
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999998846
p_ni:  0.000001154
Score:  0.23
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999992126
p_ni:  0.000007871
p_wrong:  2e-9
Data Source:  BioPlex
GATAD2A
Tbio
Novelty:  0.05599551
p_int:  0.999981601
p_ni:  0.000018399
Score:  0.726
Data Source:  BioPlex,STRINGDB
PRDM5
Tbio
Family:  TF; Epigenetic
Novelty:  0.01689997
p_int:  0.999934639
p_ni:  0.000065361
Data Source:  BioPlex
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.999890439
p_ni:  0.000109561
Data Source:  BioPlex
LLGL2
Tbio
Novelty:  0.07084531
p_int:  0.999648276
p_ni:  0.000351724
Score:  0.152
Data Source:  BioPlex,STRINGDB
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.99947794
p_ni:  0.000522056
p_wrong:  4e-9
Data Source:  BioPlex
TSPYL1
Tbio
Novelty:  0.06381144
p_int:  0.997912373
p_ni:  0.002087627
Score:  0.276
Data Source:  BioPlex,STRINGDB
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.992963383
p_ni:  0.005676779
p_wrong:  0.001359838
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
56.7
vitamin D measurement
1
1
1
48.8
gut microbiome measurement
1
1
0
5.6
42.5
lymphocyte count
1
1
1
19.6
mean corpuscular hemoglobin concentration
1
1
1
18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
56.7
vitamin D measurement
1
48.8
gut microbiome measurement
0
5.6
42.5
lymphocyte count
1
19.6
mean corpuscular hemoglobin concentration
1
18
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 687
VGNC:8142
457290
Macaque
zinc finger protein 687
716590
Mouse
MGI:1925516
78266
Rat
RGD:2323182
100363361
Dog
zinc finger protein 687
VGNC:48795
483195
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 687
Macaque
zinc finger protein 687
Mouse
Rat
Dog
zinc finger protein 687
Publication Statistics
PubMed Score 8.85
PubMed score by year
PubTator Score 2.61
PubTator score by year
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Related Publications
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PMID
Year
Title