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Tbio
ZNF653
Zinc finger protein 653

Protein Summary
Description
Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293771
  • ENSP00000293771
  • ENSG00000161914

Symbol
  • ZIP67
  • ZIP67
  • E430039K05Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
tissue sample
0.66
cell type or tissue
0.65
cell line
0.58
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.46   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.46   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
ZFP91
Tbio
Family:  TF
Novelty:  0.06937322
p_int:  0.999999677
p_ni:  6.8e-8
p_wrong:  2.56e-7
Data Source:  BioPlex
DIEXF
Tbio
Novelty:  0.05892659
p_int:  0.999834535
p_ni:  0.000165465
Data Source:  BioPlex
NSD1
Tbio
Family:  Epigenetic
Novelty:  0.00495576
p_int:  0.999563927
p_ni:  0.000435213
p_wrong:  8.6e-7
Score:  0.152
Data Source:  BioPlex,STRINGDB
YY1AP1
Tbio
Novelty:  0.06862573
p_int:  0.999239256
p_ni:  0.000760057
p_wrong:  6.87e-7
Data Source:  BioPlex
PHF8
Tchem
Family:  Epigenetic
Novelty:  0.01946151
p_int:  0.999172034
p_ni:  0.000735112
p_wrong:  0.000092854
Data Source:  BioPlex
PIP5K1A
Tbio
Family:  Kinase
Novelty:  0.05039085
p_int:  0.998481704
p_ni:  0.001518295
p_wrong:  1e-9
Data Source:  BioPlex
ZNF100
Tdark
Family:  TF
Novelty:  0.74439926
p_int:  0.997886532
p_ni:  0.001713943
p_wrong:  0.000399525
Data Source:  BioPlex
POGZ
Tbio
Novelty:  0.03603188
p_int:  0.993430958
p_ni:  0.006569027
p_wrong:  1.6e-8
Data Source:  BioPlex
NSUN5
Tbio
Family:  Enzyme
Novelty:  0.05373996
p_int:  0.98924287
p_ni:  0.010757129
p_wrong:  1e-9
Data Source:  BioPlex
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.987704191
p_ni:  0.012295809
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
2
2
89.5
Agents acting on the renin-angiotensin system use measurement
1
1
1
76.5
3
1
1
7.8
65.4
Calcium channel blocker use measurement
1
1
1
64.9
Diuretic use measurement
1
1
1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
89.5
Agents acting on the renin-angiotensin system use measurement
1
76.5
1
7.8
65.4
Calcium channel blocker use measurement
1
64.9
Diuretic use measurement
1
56.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 653
VGNC:11496
468722
Macaque
zinc finger protein 653
714754
Mouse
MGI:2442362
319601
Rat
RGD:1308754
300446
Dog
zinc finger protein 653
VGNC:48788
484939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 653
Macaque
zinc finger protein 653
Mouse
Rat
Dog
zinc finger protein 653
Publication Statistics
PubMed Score 0.46
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title