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Tbio
ZNF644
Zinc finger protein 644

Protein Summary
Description
May be involved in transcriptional regulation. The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337393
  • ENSP00000337008
  • ENSG00000122482
  • ENST00000347275
  • ENSP00000340828
  • ENST00000361321
  • ENSP00000354659
  • ENST00000370440
  • ENSP00000359469

Symbol
  • KIAA1221
  • ZEP2
  • NatF
  • MYP21
  • ZEP-2
  • BM-005
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
virus perturbation
0.9
kinase perturbation
0.76
transcription factor binding site profile
0.75
transcription factor
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.78   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.78   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
XAGE3
Tdark
Novelty:  0.1418603
p_int:  0.999999689
p_ni:  3.11e-7
Data Source:  BioPlex
XAGE2
Tbio
Novelty:  0.15338981
p_int:  0.999999478
p_ni:  5.22e-7
Score:  0.171
Data Source:  BioPlex,STRINGDB
L3MBTL1
Tchem
Family:  TF; Epigenetic
Novelty:  0.02321712
p_int:  0.999998335
p_ni:  0.000001665
Score:  0.161
Data Source:  BioPlex,STRINGDB
ZNF462
Tbio
Novelty:  0.13731082
p_int:  0.999615357
p_ni:  0.000384643
Score:  0.171
Data Source:  BioPlex,STRINGDB
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.999602211
p_ni:  0.000397789
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.99881407
p_ni:  0.001185929
Data Source:  BioPlex
SUV39H2
Tchem
Family:  Epigenetic
Novelty:  0.02232167
p_int:  0.997645134
p_ni:  0.00235486
p_wrong:  6e-9
Score:  0.303
Data Source:  BioPlex,STRINGDB
PCGF6
Tbio
Novelty:  0.07032909
p_int:  0.997632126
p_ni:  0.002367874
Data Source:  BioPlex
SUV39H1
Tchem
Family:  Epigenetic
Novelty:  0.00417439
p_int:  0.997215112
p_ni:  0.002784888
Score:  0.234
Data Source:  BioPlex,STRINGDB
CDY2A
Tdark
Family:  Epigenetic
p_int:  0.994958037
p_ni:  0.005039816
p_wrong:  0.000002147
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
6
6
94.8
C-reactive protein measurement
4
4
5
92.2
sex hormone-binding globulin measurement
4
2
4
69.9
platelet crit
1
1
1
24.5
platelet count
1
1
1
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
6
94.8
C-reactive protein measurement
5
92.2
sex hormone-binding globulin measurement
4
69.9
platelet crit
1
24.5
platelet count
1
21.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 644
VGNC:10869
469377
Macaque
zinc finger protein 644
697066
Mouse
MGI:1277212
52397
Rat
RGD:1306805
305127
Dog
zinc finger protein 644
VGNC:48784
479957
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 644
Macaque
zinc finger protein 644
Mouse
Rat
Dog
zinc finger protein 644
Publication Statistics
PubMed Score 9.78
PubMed score by year
PubTator Score 17.36
PubTator score by year
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Related Publications
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PMID
Year
Title