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Tbio
ZNF638
Zinc finger protein 638

Protein Summary
Description
Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA (PubMed:8647861). May also regulate alternative splicing of target genes during adipogenesis (By similarity). The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264447
  • ENSP00000264447
  • ENSG00000075292
  • ENST00000409544
  • ENSP00000386433
  • ENST00000410075
  • ENSP00000485608

Symbol
  • NP220
  • ZFML
  • ZFML
  • NP220
  • Zfp638
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor perturbation
0.91
transcription factor binding site profile
0.86
protein domain
0.85
ligand (protein) perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.95   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.95   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.999692853
p_ni:  0.000307147
Data Source:  BioPlex
TNFRSF13B
Tbio
Novelty:  0.00338954
p_int:  0.999595904
p_ni:  0.000404096
Data Source:  BioPlex
RNASEH1
Tchem
Family:  Enzyme
Novelty:  0.01838314
p_int:  0.999096515
p_ni:  0.000903485
Data Source:  BioPlex
GTF3C2
Tdark
Novelty:  0.1827844
p_int:  0.999087019
p_ni:  0.000912981
Score:  0.354
Data Source:  BioPlex,STRINGDB
ZNF385C
Tdark
Novelty:  2.23931637
p_int:  0.998330644
p_ni:  0.001669356
Data Source:  BioPlex
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
p_int:  0.9978165
p_ni:  0.0021835
Data Source:  BioPlex
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
p_int:  0.997368195
p_ni:  0.002631805
Score:  0.325
Data Source:  BioPlex,STRINGDB
DDX50
Tbio
Family:  Enzyme
Novelty:  0.05314506
p_int:  0.995674982
p_ni:  0.004325018
Data Source:  BioPlex
CLEC3A
Tdark
Novelty:  0.21498836
p_int:  0.990420157
p_ni:  0.009579843
Data Source:  BioPlex
GTF3C4
Tdark
Family:  Epigenetic
Novelty:  0.28198123
p_int:  0.989021581
p_ni:  0.010978419
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Transcriptional regulation of white adipocyte differentiation
Name
Explore in Pharos
Explore in Source
Developmental Biology
Transcriptional regulation of white adipocyte differentiation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
4
5
93.1
intelligence
7
13
2
5.9
81.9
BMI-adjusted hip circumference
2
5
5
76.4
mean corpuscular volume
1
1
1
73.9
mean reticulocyte volume
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
93.1
intelligence
2
5.9
81.9
BMI-adjusted hip circumference
5
76.4
mean corpuscular volume
1
73.9
mean reticulocyte volume
1
70.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 638
VGNC:475
459312
Macaque
zinc finger protein 638
704418
Mouse
MGI:1203484
18139
Rat
RGD:1309746
312491
Dog
zinc finger protein 638
VGNC:48781
475799
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 638
Macaque
zinc finger protein 638
Mouse
Rat
Dog
zinc finger protein 638
Publication Statistics
PubMed Score 10.95
PubMed score by year
PubTator Score 6.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title