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Tbio
ZNF593
Zinc finger protein 593

Protein Summary
Description
Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374266
  • ENSP00000363384
  • ENSG00000142684

Symbol
  • ZT86
  • ZT86
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
transcription factor
0.8
transcription factor binding site profile
0.76
cell type or tissue
0.67
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.91   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.91   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (213)
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.992999488
p_ni:  0.007000473
p_wrong:  3.9e-8
Data Source:  BioPlex
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.988487376
p_ni:  0.011508263
p_wrong:  0.000004361
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.975289172
p_ni:  0.024709691
p_wrong:  0.000001137
Score:  0.409
Data Source:  BioPlex,STRINGDB
ZNF385C
Tdark
Novelty:  2.23931637
p_int:  0.935880439
p_ni:  0.064097665
p_wrong:  0.000021896
Data Source:  BioPlex
THY1
Tbio
Novelty:  0.00032846
p_int:  0.901786419
p_ni:  0.098175181
p_wrong:  0.0000384
Data Source:  BioPlex
CCDC60
Tdark
Novelty:  0.62801145
p_int:  0.880776251
p_ni:  0.11921583
p_wrong:  0.00000792
Score:  0.187
Data Source:  BioPlex,STRINGDB
ZKSCAN8
Tbio
Family:  TF
Novelty:  0.17881042
p_int:  0.879726941
p_ni:  0.054368951
p_wrong:  0.065904108
Data Source:  BioPlex
NLK
Tchem
Family:  Kinase
Novelty:  0.01512201
p_int:  0.876803942
p_ni:  0.046659239
p_wrong:  0.076536819
Data Source:  BioPlex
ARRDC3
Tbio
Novelty:  0.04840692
p_int:  0.87177231
p_ni:  0.121969231
p_wrong:  0.006258459
Score:  0.179
Data Source:  BioPlex,STRINGDB
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.864288261
p_ni:  0.1356783
p_wrong:  0.000033439
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
65.5
BMI-adjusted waist-hip ratio
1
1
1
35
platelet crit
1
1
1
31.4
waist-hip ratio
1
1
1
30.2
IGF-1 measurement
1
1
1
27.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
65.5
BMI-adjusted waist-hip ratio
1
35
platelet crit
1
31.4
waist-hip ratio
1
30.2
IGF-1 measurement
1
27.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915290
68040
Rat
RGD:1310179
298546
Dog
zinc finger protein 593
100855652
Horse
zinc finger protein 593
VGNC:50793
100071195
Cow
zinc finger protein 593
508477
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
zinc finger protein 593
Horse
zinc finger protein 593
Cow
zinc finger protein 593
Publication Statistics
PubMed Score 2.91
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title