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Tdark
ZNF581
Zinc finger protein 581

Protein Summary
Description
May be involved in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270451
  • ENSP00000270451
  • ENSG00000171425
  • ENST00000587252
  • ENSP00000466047
  • ENST00000588537
  • ENSP00000466564

Symbol
  • HSPC189
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.62
cell type or tissue
0.53
tissue sample
0.51
small molecule perturbation
0.46
transcription factor
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.02   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.02   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (8)
ADNP
Tbio
Family:  TF
Novelty:  0.00785336
p_int:  0.999999935
p_ni:  4.8e-8
p_wrong:  1.7e-8
Score:  0.23
Data Source:  BioPlex,STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.999999212
p_ni:  1e-9
p_wrong:  7.87e-7
Data Source:  BioPlex
DIRAS2
Tbio
Family:  Enzyme
Novelty:  0.12334631
p_int:  0.997954797
p_ni:  0.002045146
p_wrong:  5.7e-8
Score:  0.232
Data Source:  BioPlex,STRINGDB
HIKESHI
Tbio
Novelty:  0.0683189
p_int:  0.990145349
p_ni:  0.009854648
p_wrong:  3e-9
Score:  0.23
Data Source:  BioPlex,STRINGDB
CHD4
Tchem
Family:  Epigenetic
Novelty:  0.00826969
p_int:  0.974048083
p_ni:  0.025951917
Score:  0.259
Data Source:  BioPlex,STRINGDB
ERBIN
Tbio
Novelty:  0.01419561
p_int:  0.962409058
p_ni:  0.037590942
Score:  0.18
Data Source:  BioPlex,STRINGDB
DMWD
Tbio
Novelty:  0.04096001
p_int:  0.935598004
p_ni:  0.064401995
Score:  0.212
Data Source:  BioPlex,STRINGDB
NT5C
Tbio
Family:  Enzyme
Novelty:  0.00686933
p_int:  0.89707841
p_ni:  0.102880195
p_wrong:  0.000041395
Score:  0.242
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
2
3
72.7
insomnia measurement
1
2
0
1.1
56.3
high density lipoprotein cholesterol measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
72.7
insomnia measurement
0
1.1
56.3
high density lipoprotein cholesterol measurement
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 581
VGNC:11508
737491
Macaque
zinc finger protein 581
100428425
Dog
zinc finger protein 581
VGNC:48765
106559556
Horse
zinc finger protein 581
VGNC:25349
100146606
Cow
zinc finger protein 581
VGNC:37306
618894
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 581
Macaque
zinc finger protein 581
Dog
zinc finger protein 581
Horse
zinc finger protein 581
Cow
zinc finger protein 581
Publication Statistics
PubMed Score 0.02
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title