Tdark ZNF581 Zinc finger protein 581

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q9P0T4
• B2RDM6

Gene Name

• ZNF581

Ensembl ID

• ENST00000270451
• ENSP00000270451
• ENSG00000171425
• ENST00000587252
• ENSP00000466047
• ENST00000588537
• ENSP00000466564

Symbol

• HSPC189

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.62
cell type or tissue	0.53
tissue sample	0.51
small molecule perturbation	0.46
transcription factor	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.02   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 58   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.02   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (8)

Explore Interacting Targets

1 – 8 of 8

• See Interactions on String-DB

ADNP

Tbio

Family:  TF

Novelty:  0.00785336

p_int:  0.999999935

p_ni:  4.8e-8

p_wrong:  1.7e-8

Score:  0.23

Data Source:  BioPlex,STRINGDB

CHCHD4

Tbio

Novelty:  0.01204944

p_int:  0.999999212

p_ni:  1e-9

p_wrong:  7.87e-7

Data Source:  BioPlex

DIRAS2

Tbio

Family:  Enzyme

Novelty:  0.12334631

p_int:  0.997954797

p_ni:  0.002045146

p_wrong:  5.7e-8

Score:  0.232

Data Source:  BioPlex,STRINGDB

HIKESHI

Tbio

Novelty:  0.0683189

p_int:  0.990145349

p_ni:  0.009854648

p_wrong:  3e-9

Score:  0.23

Data Source:  BioPlex,STRINGDB

CHD4

Tchem

Family:  Epigenetic

Novelty:  0.00826969

p_int:  0.974048083

p_ni:  0.025951917

Score:  0.259

Data Source:  BioPlex,STRINGDB

ERBIN

Tbio

Novelty:  0.01419561

p_int:  0.962409058

p_ni:  0.037590942

Score:  0.18

Data Source:  BioPlex,STRINGDB

DMWD

Tbio

Novelty:  0.04096001

p_int:  0.935598004

p_ni:  0.064401995

Score:  0.212

Data Source:  BioPlex,STRINGDB

NT5C

Tbio

Family:  Enzyme

Novelty:  0.00686933

p_int:  0.89707841

p_ni:  0.102880195

p_wrong:  0.000041395

Score:  0.242

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	3	2	3		72.7
insomnia measurement	EFO_0007876	1	2	0	1.1	56.3
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	3		72.7
insomnia measurement	EFO_0007876	0	1.1	56.3
high density lipoprotein cholesterol measurement	EFO_0004612	1		21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
DNA-binding
Metal-binding
Nucleus
Reference proteome
Repeat
Transcription
Transcription regulation
Zinc
Zinc-finger

GWAS Trait Find Similar Targets

No Header	No Header
high density lipoprotein cholesterol measurement
insomnia measurement
triglyceride measurement

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 581	VGNC:11508	737491
Macaque	zinc finger protein 581		100428425
Dog	zinc finger protein 581	VGNC:48765	106559556
Horse	zinc finger protein 581	VGNC:25349	100146606
Cow	zinc finger protein 581	VGNC:37306	618894

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 581
Macaque	zinc finger protein 581
Dog	zinc finger protein 581
Horse	zinc finger protein 581
Cow	zinc finger protein 581

Publication Statistics

PubMed Score 0.02

PubMed score by year

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Related Publications

Text Mined References (6)

Items per page:

10

0 of 0

PMID	Year	Title