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Tdark
ZNF577
Zinc finger protein 577

Protein Summary
Description
May be involved in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301399
  • ENSP00000301399
  • ENSG00000161551
  • ENST00000451628
  • ENSP00000389652
  • ENST00000639636
  • ENSP00000491349
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.95
histone modification site profile
0.64
virus perturbation
0.64
tissue
0.62
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.4   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.4   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (10)
MAPKAPK5
Tchem
Family:  Kinase
Novelty:  0.01349079
p_int:  0.999611145
p_ni:  0.000388854
p_wrong:  1e-9
Data Source:  BioPlex
DDI2
Tbio
Novelty:  0.09288646
p_int:  0.999044338
p_ni:  0.000955662
Data Source:  BioPlex
CHAC2
Tbio
Family:  Enzyme
Novelty:  0.14706039
p_int:  0.854627241
p_ni:  0.145368448
p_wrong:  0.000004312
Data Source:  BioPlex
INTS3
Tbio
Novelty:  0.13398603
p_int:  0.766487492
p_ni:  0.233512508
Data Source:  BioPlex
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.903
Data Source:  STRINGDB
C12orf42
Tdark
Novelty:  0.80357443
Score:  0.512
Data Source:  STRINGDB
VMAC
Tdark
Novelty:  0.83333333
Score:  0.426
Data Source:  STRINGDB
ROPN1L
Tbio
Novelty:  0.18077695
Score:  0.422
Data Source:  STRINGDB
FBXL17
Tbio
Novelty:  0.16122137
Score:  0.413
Data Source:  STRINGDB
SIGLEC5
Tbio
Novelty:  0.02616618
Score:  0.402
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
5
7
93.8
blood protein measurement
2
2
2
75.1
eosinophil count
2
2
2
72.4
eosinophil percentage of leukocytes
1
1
1
60.8
apolipoprotein A 1 measurement
1
1
1
51
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
93.8
blood protein measurement
2
75.1
eosinophil count
2
72.4
eosinophil percentage of leukocytes
1
60.8
apolipoprotein A 1 measurement
1
51
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 577
748901
Macaque
zinc finger protein 577
720041
Dog
zinc finger protein 577
491432
Horse
zinc finger protein 577 [Source:HGNC Symbol;Acc:HGNC:28673]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 577
Macaque
zinc finger protein 577
Dog
zinc finger protein 577
Horse
zinc finger protein 577 [Source:HGNC Symbol;Acc:HGNC:28673]
Publication Statistics
PubMed Score 4.40
PubMed score by year
PubTator Score 1.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title