Tdark ZNF558 Zinc finger protein 558

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q96NG5
• A8K5F0
• B7Z798

Gene Name

• ZNF558

Ensembl ID

• ENST00000301475
• ENSP00000301475
• ENSG00000167785
• ENST00000601372
• ENSP00000471277

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.64
protein domain	0.58
microRNA	0.51
cell line	0.5
tissue	0.46

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein 558

Protein / ... / Krab Box Transcription Factor / Zinc Finger Protein 558

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Zinc Finger Protein 558

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (22)

Explore Interacting Targets

1 – 10 of 22

• See Interactions on String-DB

APOA1

Tbio

Novelty:  0.0001216

p_int:  0.999627071

p_ni:  0.000372898

p_wrong:  3.1e-8

Score:  0.261

Data Source:  BioPlex,STRINGDB

SERPINA1

Tbio

Novelty:  0.00014098

p_int:  0.990115269

p_ni:  0.009884687

p_wrong:  4.4e-8

Score:  0.236

Data Source:  BioPlex,STRINGDB

RCBTB2

Tbio

Novelty:  0.04244536

p_int:  0.944975306

p_ni:  0.034361337

p_wrong:  0.020663358

Score:  0.52

Data Source:  BioPlex,STRINGDB

FTL

Tbio

Novelty:  0.00235168

p_int:  0.822749059

p_ni:  0.177246919

p_wrong:  0.000004022

Score:  0.195

Data Source:  BioPlex,STRINGDB

ALB

Tchem

Novelty:  0.00000616

p_int:  0.763966469

p_ni:  0.236033531

Score:  0.261

Data Source:  BioPlex,STRINGDB

TRIM28

Tbio

Family:  Epigenetic

Novelty:  0.00778381

Score:  0.903

Data Source:  STRINGDB

OR2Z1

Tdark

Family:  oGPCR

Novelty:  1.80952381

Score:  0.699

Data Source:  STRINGDB

TRIM61

Tdark

Novelty:  0.46482206

Score:  0.605

Data Source:  STRINGDB

ZZZ3

Tdark

Family:  TF

Novelty:  0.23862921

Score:  0.542

Data Source:  STRINGDB

UBL4B

Tdark

Novelty:  0.56877836

Score:  0.541

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cancer antigen 125 measurement	EFO_0010603	1	1	1		68.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cancer antigen 125 measurement	EFO_0010603	1		68.6

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
DNA-binding
Metal-binding
Nucleus
Reference proteome
Repeat
Transcription
Transcription regulation
Zinc

GWAS Trait Find Similar Targets

No Header	No Header
cancer antigen 125 measurement

IDG Resources

No IDG generated resources found

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	zinc finger protein 558	MGI:1921681	72230
Horse	zinc finger protein 558		100064134
Pig	zinc finger protein 558		100514703

Species	Name	OMA	EggNOG	Inparanoid
Mouse	zinc finger protein 558
Horse	zinc finger protein 558
Pig	zinc finger protein 558

Publication Statistics

PubMed Score 1.84

PubMed score by year

Reset Zoom

PubTator Score 0.50

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (6)

Items per page:

10

0 of 0

PMID	Year	Title