Tdark ZNF554 Zinc finger protein 554

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q86TJ5
• Q8NAT3
• Q9BWN3

Gene Name

• ZNF554

Ensembl ID

• ENST00000317243
• ENSP00000321132
• ENSG00000172006

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
tissue sample	0.65
protein domain	0.58
cell line	0.53
histone modification site profile	0.52

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein 554

Protein / ... / Krab Box Transcription Factor / Zinc Finger Protein 554

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Zinc Finger Protein 554

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.2   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.2   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (11)

Explore Interacting Targets

1 – 10 of 11

• See Interactions on String-DB

SAV1

Tbio

Novelty:  0.00962335

p_int:  0.999982276

p_ni:  0.000017724

Data Source:  BioPlex

ZNF808

Tdark

Family:  TF

Novelty:  0.83652177

p_int:  0.999969917

p_ni:  2e-9

p_wrong:  0.00003008

Data Source:  BioPlex

TRIM37

Tbio

Family:  Enzyme

Novelty:  0.02515451

p_int:  0.998894369

p_ni:  0.000812141

p_wrong:  0.000293489

Data Source:  BioPlex

STK3

Tchem

Family:  Kinase

Novelty:  0.0529257

p_int:  0.997876146

p_ni:  0.002123854

Data Source:  BioPlex

STK4

Tchem

Family:  Kinase

Novelty:  0.02104423

p_int:  0.994363622

p_ni:  0.005636378

Data Source:  BioPlex

TRIM28

Tbio

Family:  Epigenetic

Novelty:  0.00778381

p_int:  0.989176876

p_ni:  0.010823124

Score:  0.947

Data Source:  BioPlex,STRINGDB

MYADM

Tbio

Novelty:  0.11475375

Score:  0.567

Data Source:  STRINGDB

ZNF474

Tdark

Novelty:  1.18085106

Score:  0.511

Data Source:  STRINGDB

HMCES

Tbio

Family:  Enzyme

Novelty:  0.01229889

Score:  0.44

Data Source:  STRINGDB

SETDB1

Tbio

Family:  TF; Epigenetic

Novelty:  0.00609294

Score:  0.43

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (3)

Components (2)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6	3	6		97.4
testosterone measurement	EFO_0004908	4	4	4		91.8
coronary artery disease	EFO_0001645	1	1	0	25	78.6
myocardial infarction	EFO_0000612	1	1	0	50	76.5
low density lipoprotein cholesterol measurement	EFO_0004611	3	3	3		64.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6		97.4
testosterone measurement	EFO_0004908	4		91.8
coronary artery disease	EFO_0001645	0	25	78.6
myocardial infarction	EFO_0000612	0	50	76.5
low density lipoprotein cholesterol measurement	EFO_0004611	3		64.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
coronary artery disease
Ischemic stroke
low density lipoprotein cholesterol measurement
myocardial infarction
platelet count
platelet crit
sex hormone-binding globulin measurement
testosterone measurement
total cholesterol measurement

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 554	VGNC:2147	744575
Macaque	zinc finger protein 554		711821
Dog	zinc finger protein 554	VGNC:48759	100686725
Horse	zinc finger protein 554	VGNC:25341	100060272
Cow	zinc finger protein 554	VGNC:37301	100125579

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 554
Macaque	zinc finger protein 554
Dog	zinc finger protein 554
Horse	zinc finger protein 554
Cow	zinc finger protein 554

Publication Statistics

PubMed Score 1.20

PubMed score by year

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PubTator Score 0.25

PubTator score by year

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Related Publications

Text Mined References (5)

Items per page:

10

0 of 0

PMID	Year	Title