Tdark ZNF550 Zinc finger protein 550

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q7Z398
• B3KVF6
• O43337
• Q7Z6D7
• Q8NE45

Gene Name

• ZNF550

Ensembl ID

• ENST00000325134
• ENSP00000446224
• ENSG00000251369
• ENST00000376230
• ENSP00000469537
• ENST00000447310
• ENSP00000469580
• ENST00000457177
• ENSP00000469679

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
cell type or tissue	0.58
protein domain	0.58
tissue	0.57
cell line	0.52

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein 550

Protein / ... / Krab Box Transcription Factor / Zinc Finger Protein 550

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Zinc Finger Protein 550

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.07   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 123   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.07   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (46)

Explore Interacting Targets

1 – 10 of 46

• See Interactions on String-DB

MEIOC

Tdark

Novelty:  0.85732988

p_int:  0.999999956

p_ni:  4e-8

p_wrong:  4e-9

Score:  0.189

Data Source:  BioPlex,STRINGDB

ZNF714

Tdark

Family:  TF

Novelty:  0.73743398

p_int:  0.999998097

p_ni:  7.77e-7

p_wrong:  0.000001126

Score:  0.187

Data Source:  BioPlex,STRINGDB

YTHDC2

Tbio

Family:  Enzyme

Novelty:  0.05211009

p_int:  0.999968415

p_ni:  0.000031585

Score:  0.151

Data Source:  BioPlex,STRINGDB

TRIM37

Tbio

Family:  Enzyme

Novelty:  0.02515451

p_int:  0.998923964

p_ni:  0.001059484

p_wrong:  0.000016552

Score:  0.169

Data Source:  BioPlex,STRINGDB

ZNF460

Tdark

Family:  TF

Novelty:  0.71547663

p_int:  0.998316161

p_ni:  0.001683174

p_wrong:  6.65e-7

Data Source:  BioPlex

ZNF92

Tbio

Family:  TF

Novelty:  0.05724663

p_int:  0.997249948

p_ni:  0.002750052

Data Source:  BioPlex

RBAK

Tbio

Family:  TF

Novelty:  0.12597665

p_int:  0.997109058

p_ni:  0.002889476

p_wrong:  0.000001466

Data Source:  BioPlex

USP34

Tbio

Family:  Enzyme

Novelty:  0.16444192

p_int:  0.997054463

p_ni:  0.002945529

p_wrong:  8e-9

Score:  0.198

Data Source:  BioPlex,STRINGDB

TRIM41

Tbio

Family:  Enzyme

Novelty:  0.17238173

p_int:  0.995862118

p_ni:  0.004137758

p_wrong:  1.23e-7

Score:  0.158

Data Source:  BioPlex,STRINGDB

FBLN5

Tbio

Novelty:  0.00599598

p_int:  0.994504495

p_ni:  0.004422383

p_wrong:  0.001073123

Score:  0.191

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	4	3	4		90.6
mean reticulocyte volume	EFO_0010701	1	1	1		62.1
balding measurement	EFO_0007825	1	1	1		24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	4		90.6
mean reticulocyte volume	EFO_0010701	1		62.1
balding measurement	EFO_0007825	1		24.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
DNA-binding
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
mean reticulocyte volume
red blood cell distribution width

IDG Resources

No IDG generated resources found

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 550	VGNC:11468	456330
Macaque	zinc finger protein 550		106994887
Dog	zinc finger protein 550	VGNC:48758	102155260

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 550
Macaque	zinc finger protein 550
Dog	zinc finger protein 550

Publication Statistics

PubMed Score 0.07

PubMed score by year

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Related Publications

Text Mined References (8)

Items per page:

10

0 of 0

PMID	Year	Title