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Tdark
ZNF518A
Zinc finger protein 518A

Protein Summary
Description
May be involved in transcriptional regulation. The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Numerous transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316045
  • ENSP00000479684
  • ENSG00000177853
  • ENST00000614149
  • ENSP00000481657
  • ENST00000624776
  • ENSP00000485614

Symbol
  • KIAA0335
  • ZNF518
  • ZNF518
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
microRNA
0.69
transcription factor
0.69
tissue sample
0.63
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.4   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.4   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
NUP62CL
Tdark
Novelty:  2.93223607
p_int:  0.999986085
p_ni:  0.000013911
p_wrong:  3e-9
Data Source:  BioPlex
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.999942655
p_ni:  0.000057345
Data Source:  BioPlex
PCDHA12
Tdark
Novelty:  0.71618264
p_int:  0.999517747
p_ni:  0.00048225
p_wrong:  4e-9
Score:  0.464
Data Source:  BioPlex,STRINGDB
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.997454831
p_ni:  0.002545132
p_wrong:  3.6e-8
Data Source:  BioPlex
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.996562945
p_ni:  0.003433779
p_wrong:  0.000003276
Data Source:  BioPlex
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.988894929
p_ni:  0.01109689
p_wrong:  0.000008181
Score:  0.187
Data Source:  BioPlex,STRINGDB
XPA
Tchem
Novelty:  0.00137698
p_int:  0.988136228
p_ni:  0.007640973
p_wrong:  0.004222798
Score:  0.513
Data Source:  BioPlex,STRINGDB
EIPR1
Tbio
Novelty:  0.08803081
p_int:  0.984978196
p_ni:  0.010919329
p_wrong:  0.004102475
Data Source:  BioPlex
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.984279644
p_ni:  0.0103232
p_wrong:  0.005397156
Data Source:  BioPlex
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.965669743
p_ni:  0.034320941
p_wrong:  0.000009316
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
56.6
mean corpuscular volume
1
1
1
46.1
sex hormone-binding globulin measurement
4
1
4
29.9
BMI-adjusted waist circumference
1
1
1
26.1
aging
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
56.6
mean corpuscular volume
1
46.1
sex hormone-binding globulin measurement
4
29.9
BMI-adjusted waist circumference
1
26.1
aging
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 518A
704154
Mouse
MGI:1919922
72672
Rat
RGD:1305314
309478
Dog
zinc finger protein 518A
VGNC:48748
100687589
Cow
zinc finger protein 518A
VGNC:37295
524691
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 518A
Mouse
Rat
Dog
zinc finger protein 518A
Cow
zinc finger protein 518A
Publication Statistics
PubMed Score 0.40
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title