Tdark ZNF490 Zinc finger protein 490

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q9ULM2

Gene Name

• ZNF490

Ensembl ID

• ENST00000311437
• ENSP00000311521
• ENSG00000188033

Symbol

• KIAA1198

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.76
histone modification site profile	0.71
tissue sample	0.7
tissue	0.69
cell line	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.36   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 79   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.36   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (32)

Explore Interacting Targets

1 – 10 of 32

• See Interactions on String-DB

TRIM39

Tbio

Family:  Enzyme

Novelty:  0.0837441

p_int:  0.998439379

p_ni:  0.001560621

Score:  0.201

Data Source:  BioPlex,STRINGDB

RPL36AL

Tbio

Novelty:  0.09336423

p_int:  0.990050262

p_ni:  0.009949737

p_wrong:  1e-9

Data Source:  BioPlex

EEF1A2

Tchem

Novelty:  0.001472

p_int:  0.947445094

p_ni:  0.052554906

Data Source:  BioPlex

TOMM34

Tbio

Novelty:  0.05433718

p_int:  0.906485048

p_ni:  0.093216765

p_wrong:  0.000298187

Score:  0.206

Data Source:  BioPlex,STRINGDB

PRDM15

Tbio

Family:  TF; Epigenetic

Novelty:  0.17392284

p_int:  0.895366594

p_ni:  0.104633035

p_wrong:  3.72e-7

Score:  0.214

Data Source:  BioPlex,STRINGDB

NEMF

Tbio

Novelty:  0.05052246

p_int:  0.893632549

p_ni:  0.106367451

Score:  0.187

Data Source:  BioPlex,STRINGDB

RPL26L1

Tdark

Novelty:  0.75408617

p_int:  0.798932529

p_ni:  0.201067471

Data Source:  BioPlex

TRIM28

Tbio

Family:  Epigenetic

Novelty:  0.00778381

Score:  0.913

Data Source:  STRINGDB

BLOC1S5

Tbio

Novelty:  0.17565466

Score:  0.724

Data Source:  STRINGDB

BLOC1S2

Tbio

Novelty:  0.02346362

Score:  0.705

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cathepsin L1 measurement	EFO_0010619	1	1	1		42.3
body height	EFO_0004339	1	1	1		24.5
emphysema	EFO_0000464	1	1	1		8.3
mathematical ability	EFO_0004875	1	1	1		2.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cathepsin L1 measurement	EFO_0010619	1		42.3
body height	EFO_0004339	1		24.5
emphysema	EFO_0000464	1		8.3
mathematical ability	EFO_0004875	1		2.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
DNA-binding
Metal-binding
Nucleus
Reference proteome
Repeat
Transcription
Transcription regulation
Zinc
Zinc-finger

GWAS Trait Find Similar Targets

No Header	No Header
body height
cathepsin L1 measurement
emphysema
mathematical ability

IDG Resources

No IDG generated resources found

Orthologs (1)

1 – 1 of 1

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	zinc finger protein 490		100426568

Species	Name	OMA	EggNOG	Inparanoid
Macaque	zinc finger protein 490

Publication Statistics

PubMed Score 0.36

PubMed score by year

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PubTator Score 0.35

PubTator score by year

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Related Publications

Text Mined References (6)

Items per page:

10

0 of 0

PMID	Year	Title