ZNF473
Zinc finger protein 473
Protein Summary
Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases. This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]
- ENST00000270617
- ENSP00000270617
- ENSG00000142528
- ENST00000391821
- ENSP00000375697
- ENST00000595661
- ENSP00000472808
- KIAA1141
- ZFP100
- ZN473
- ZFP100
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
virus perturbation | 0.85 | ||
transcription factor | 0.67 | ||
microRNA | 0.61 | ||
transcription factor binding site profile | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.64 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 117 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.64 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 117 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0